Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis

Taresco, V., Creasey, R. G., Kennon, J., Mantovani, G., Alexander, C., Burley, J. C. and Garnett, M. C. (2016) Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis. Polymer, 89 41-49. doi:10.1016/j.polymer.2016.02.036


Author Taresco, V.
Creasey, R. G.
Kennon, J.
Mantovani, G.
Alexander, C.
Burley, J. C.
Garnett, M. C.
Title Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis
Journal name Polymer   Check publisher's open access policy
ISSN 0032-3861
1873-2291
Publication date 2016-04-20
Sub-type Article (original research)
DOI 10.1016/j.polymer.2016.02.036
Volume 89
Start page 41
End page 49
Total pages 9
Place of publication London, United Kingdom
Publisher Elsevier Ltd
Collection year 2017
Language eng
Formatted abstract
Poly (glycerol adipate) (PGA) can be produced from divinyl adipate and unprotected glycerol by an enzymatic route to generate a polymer with relatively low molar mass (12 kDa). PGA bears a pendant hydroxyl group which imparts a hydrophilic character to this water insoluble polymer. We have examined the effect of synthesis temperature on polymer characteristics through various techniques including FT-IR, 1H and 13C NMR, surface and thermal analysis, both to expand the data already present in the literature about this material and to understand better its properties for potential pharmaceutical applications. The use of a lipase (Novozym 435) as a catalyst suppresses cross-linking at the pendant glyceryl hydroxyl through steric hindrance at the active site, thus producing polymers with low degrees of branching (5–30%), and removes the need for any pre- or post-polymerization protection/deprotection reactions. Careful temperature control during synthesis can give polymers with reproducible molecular weights and reduced amounts of polymer branching compared to synthesis at higher temperatures. Due to the ability of the synthetic route to produce a range of structures, PGA generated by enzymatic routes may emerge as a useful biodegradable polymer platform to engineer solid dispersions or nanoparticles for healthcare applications.
Keyword Biocatalysis
Biomedical polymers
Enzymatic polymerization
Poly(glycerol adipate)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
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Created: Wed, 11 May 2016, 13:45:46 EST by Noni Creasey on behalf of Learning and Research Services (UQ Library)