Reliability of structural connectivity examined with four different diffusion reconstruction methods at two different spatial and angular resolutions

Villalon-Reina, J. E., Nir, T. M., Zhan, L., McMahon, K. L., de Zubicaray, G. I., Wright, M. J., Jahanshad, N. and Thompson, P. M. (2016). Reliability of structural connectivity examined with four different diffusion reconstruction methods at two different spatial and angular resolutions. In: Andrea Fuster, Aurobrata Ghosh, Enrico Kaden, Yogesh Rathi and Marco Reisert, Workshop on Computational Diffusion MRI, MICCAI 2015. Workshop on Computational Diffusion MRI, MICCAI 2015, Munich, Germany, (219-231). 9-9 October 2015. doi:10.1007/978-3-319-28588-7_19


Author Villalon-Reina, J. E.
Nir, T. M.
Zhan, L.
McMahon, K. L.
de Zubicaray, G. I.
Wright, M. J.
Jahanshad, N.
Thompson, P. M.
Title of paper Reliability of structural connectivity examined with four different diffusion reconstruction methods at two different spatial and angular resolutions
Conference name Workshop on Computational Diffusion MRI, MICCAI 2015
Conference location Munich, Germany
Conference dates 9-9 October 2015
Proceedings title Workshop on Computational Diffusion MRI, MICCAI 2015   Check publisher's open access policy
Journal name Mathematics and Visualization   Check publisher's open access policy
Series Mathematics and visualization
Place of Publication Switzerland
Publisher Springer
Publication Year 2016
Year available 2016
Sub-type Fully published paper
DOI 10.1007/978-3-319-28588-7_19
Open Access Status Not Open Access
ISBN 9783319285863
9783319285887
ISSN 1612-3786
2197-666X
Editor Andrea Fuster
Aurobrata Ghosh
Enrico Kaden
Yogesh Rathi
Marco Reisert
Start page 219
End page 231
Total pages 13
Chapter number 19
Total chapters 19
Collection year 2017
Language eng
Abstract/Summary Diffusion magnetic resonance imaging (dMRI) has had a great impact on the study of the human brain connectome. Tractography methods allow for the reconstruction of white matter fiber tracts and bundles across the brain, by tracing the estimated direction of water diffusion across neighboring voxels. The tracts can then be used in conjunction with cortical parcellations to create structural connectivity matrices, to map the pattern and distribution of connections between cortical regions. However, the reliability of connectivity matrices is unclear. Tractography results depend on image resolution, and some reconstruction methods used to resolve the voxel-wise microstructure may be more robust to changes in resolution than others, leading to more stable connectivity estimates. We examined the reliability of structural connectivity matrices in 20 healthy young adults imaged with both high and low-resolution dMRI at two time points. We found that the Constrained Spherical Deconvolution (CSD) model produces the most reliable connections for both lower resolution and high resolution scans.
Keyword Diffusion magnetic resonance imaging
Structural connectivity
Test-retest reliability
Tractography
White matter
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

 
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