Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma

Attia, Amalina Binte Ebrahim, Ho, Chris Jun Hui, Chandrasekharan, Prashant, Balasundaram, Ghayathri, Tay, Hui Chien, Burton, Neal C., Chuang, Kai-Hsiang, Ntziachristos, Vasilis and Olivo, Malini (2016) Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma. Journal of Biophotonics, 9 7: 701-708. doi:10.1002/jbio.201500321


Author Attia, Amalina Binte Ebrahim
Ho, Chris Jun Hui
Chandrasekharan, Prashant
Balasundaram, Ghayathri
Tay, Hui Chien
Burton, Neal C.
Chuang, Kai-Hsiang
Ntziachristos, Vasilis
Olivo, Malini
Title Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma
Journal name Journal of Biophotonics   Check publisher's open access policy
ISSN 1864-0648
1864-063X
Publication date 2016-07
Year available 2016
Sub-type Article (original research)
DOI 10.1002/jbio.201500321
Open Access Status Not Open Access
Volume 9
Issue 7
Start page 701
End page 708
Total pages 8
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Collection year 2017
Language eng
Formatted abstract
Multi-modality imaging methods are of great importance in oncologic studies for acquiring complementary information, enhancing the efficacy in tumor detection and characterization. We hereby demonstrate a hybrid non-invasive in vivo imaging approach of utilizing magnetic resonance imaging (MRI) and Multispectral Optoacoustic Tomography (MSOT) for molecular imaging of glucose uptake in an orthotopic glioblastoma in mouse. The molecular and functional information from MSOT can be overlaid on MRI anatomy via image coregistration to provide insights into probe uptake in the brain, which is verified by ex vivo fluorescence imaging and histological validation. In vivo MSOT and MRI imaging of an orthotopic glioma mouse model injected with IRDye800-2DG. Image coregistration between MSOT and MRI enables multifaceted (anatomical, functional, molecular) information from MSOT to be overlaid on MRI anatomy images to derive tumor physiological parameters such as perfusion, haemoglobin and oxygenation.
Keyword Bioimaging
Coregistration
Image processing
MRI
Photoacoustic imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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