Comprehensive review of platelet storage methods for use in the treatment of active hemorrhage

Milford, Elissa M. and Reade, Michael C. (2016) Comprehensive review of platelet storage methods for use in the treatment of active hemorrhage. Transfusion, 56 S2: S140-S148. doi:10.1111/trf.13504


Author Milford, Elissa M.
Reade, Michael C.
Title Comprehensive review of platelet storage methods for use in the treatment of active hemorrhage
Journal name Transfusion   Check publisher's open access policy
ISSN 1537-2995
0041-1132
Publication date 2016-04-21
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/trf.13504
Open Access Status Not Open Access
Volume 56
Issue S2
Start page S140
End page S148
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Abstract This review considers the various methods currently in use, or under investigation, for the storage of platelets intended for use in the treatment of active hemorrhage. The current standard practice of storing platelets at room temperature (RT) (20°C-24°C) optimizes circulating time, but at the expense of hemostatic function and logistical considerations. A number of alternatives are under investigation. Novel storage media additives appear to attenuate the deleterious changes that affect RT stored platelets. Cold storage was originally abandoned due to the poor circulating time of platelets stored at 4°C, but such platelets may actually be more hemostatically effective, with a number of other advantages, compared to RT stored platelets. Periodically re-warming cold stored platelets (temperature cycling, TC) may combine the hemostatic efficacy of cold stored platelets with the longer circulating times of RT storage. Alternatives to liquid storage include cryopreservation (freezing) or lyophilization (freeze-drying). The former has had some limited clinical use and larger clinical trials are underway, while the latter is still in the preclinical stage with promising in vitro and in vivo results. The importance of platelet transfusion in the management of active hemorrhage is now well accepted, so it is timely that platelet storage methods are reviewed with consideration of not only their circulating time, but also their hemostatic efficacy.
Keyword Platelet storage
Active hemorrhage
Hemostatic function
Hemostatic efficacy
Transfusion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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