The use and risks of antibiotics in critically ill patients

Denny, Kerina J., Cotta, Menino O., Parker, Suzanne L., Roberts, Jason A. and Lipman, Jeffrey (2016) The use and risks of antibiotics in critically ill patients. Expert Opinion on Drug Safety, 15 5: 667-678. doi:10.1517/14740338.2016.1164690

Author Denny, Kerina J.
Cotta, Menino O.
Parker, Suzanne L.
Roberts, Jason A.
Lipman, Jeffrey
Title The use and risks of antibiotics in critically ill patients
Journal name Expert Opinion on Drug Safety   Check publisher's open access policy
ISSN 1744-764X
Publication date 2016-04-07
Year available 2016
Sub-type Article (original research)
DOI 10.1517/14740338.2016.1164690
Open Access Status Not Open Access
Volume 15
Issue 5
Start page 667
End page 678
Total pages 12
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2017
Language eng
Formatted abstract
Introduction: The altered pathophysiology in critically ill patients presents a unique challenge in both the diagnosis of infection and the appropriate prescription of antibiotics. In this context, the importance of effective and timely treatment needs to be weighed against the individual and community harms associated with antibiotic collateral damage and antibiotic resistance.

Areas Covered: We evaluate the principles of antibiotic use in critically ill patients, including dose optimisation, use of combination antibiotic therapy, therapeutic drug monitoring, appropriate antibiotic therapy duration, de-escalation, and utilisation of sepsis biomarkers. We also describe the potential risks associated with antibiotic therapy including antibiotic resistance, delayed treatment, treatment failure, and collateral damage.

Expert Opinion: Prescribing teams must be aware of the impact of critical illness on their patients and tailor antibiotic therapy appropriately to prevent the significant harms associated with suboptimal antibiotic administration.
Keyword Antibiotics
Critical illness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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School of Pharmacy Publications
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