Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds

Homberg, Judith R., Kyzar, Evan J., Scattoni, Maria Luisa, Norton, William H., Pittman, Julian, Gaikwad, Siddharth, Nguyen, Michael, Poudel, Manjo K., Ullmann, Jeremy F. P., Diamond, David M., Kaluyeva, Aleksandra A., Parker, Matthew O., Brown, Richard E., Song, Cai, Gainetdinov, Raul R., Gottesman, Irving I. and Kalueff, Allan V. (2016) Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds. Brain Research Bulletin, 125 79-91. doi:10.1016/j.brainresbull.2016.04.015


Author Homberg, Judith R.
Kyzar, Evan J.
Scattoni, Maria Luisa
Norton, William H.
Pittman, Julian
Gaikwad, Siddharth
Nguyen, Michael
Poudel, Manjo K.
Ullmann, Jeremy F. P.
Diamond, David M.
Kaluyeva, Aleksandra A.
Parker, Matthew O.
Brown, Richard E.
Song, Cai
Gainetdinov, Raul R.
Gottesman, Irving I.
Kalueff, Allan V.
Title Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds
Journal name Brain Research Bulletin   Check publisher's open access policy
ISSN 1873-2747
0361-9230
Publication date 2016-07-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.brainresbull.2016.04.015
Open Access Status Not Open Access
Volume 125
Start page 79
End page 91
Total pages 13
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2017
Language eng
Abstract Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs.
Keyword Experimental model
Model organism
Neurodevelopmental disorder
Preclinical study
Translational research
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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