Silica nanopollens enhance adhesion for long-term bacterial inhibition

Song, Hao, Ahmad Nor, Yusilawati, Yu, Meihua, Yang, Yannan, Zhang, Jun, Zhang, Hongwei, Xu, Chun, Mitter, Neena and Yu, Chengzhong (2016) Silica nanopollens enhance adhesion for long-term bacterial inhibition. Journal of the Americal Chemical Society, 138 20: 6455-6462. doi:10.1021/jacs.6b00243

Author Song, Hao
Ahmad Nor, Yusilawati
Yu, Meihua
Yang, Yannan
Zhang, Jun
Zhang, Hongwei
Xu, Chun
Mitter, Neena
Yu, Chengzhong
Title Silica nanopollens enhance adhesion for long-term bacterial inhibition
Journal name Journal of the Americal Chemical Society   Check publisher's open access policy
ISSN 0002-7863
Publication date 2016-05
Sub-type Article (original research)
DOI 10.1021/jacs.6b00243
Volume 138
Issue 20
Start page 6455
End page 6462
Total pages 8
Place of publication Washington DC, United States
Publisher American Chemical Society
Collection year 2017
Language eng
Formatted abstract
Nature’s creations with spiky topological features typically exhibit intriguing surface adhesive properties. From micrometer-sized pollen grains that can easily stick to hairy insects for pollination to nanoscale virus particles that are highly infectious toward host cells, multivalent interactions are formed taking advantage of rough surfaces. Herein, this nature-inspired concept is employed to develop novel drug delivery nanocarriers for antimicrobial applications. A facile new approach is developed to fabricate silica nanopollens (mesoporous silica nanospheres with rough surfaces), which show enhanced adhesion toward bacteria surfaces compared to their counterparts with smooth surfaces. Lysozyme, a natural antimicrobial enzyme, is loaded into silica nanopollens and shows sustained release behavior, potent antimicrobial activity, and long-term total bacterial inhibition up to 3 days toward Escherichia coli. The potent antibacterial activity of lysozyme-loaded silica nanopollens is further demonstrated ex vivo by using a small-intestine infection model. Our strategy provides a novel pathway in the rational design of nanocarriers for efficient drug delivery.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Mon, 09 May 2016, 10:44:03 EST by Dr Neena Mitter on behalf of Centre for Plant Science