Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation

Ullah, Md Ashik, Hill, Geoffrey R. and Tey, Siok-Keen (2016) Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation. Frontiers in Immunology, 7 . doi:10.3389/fimmu.2016.00144


Author Ullah, Md Ashik
Hill, Geoffrey R.
Tey, Siok-Keen
Title Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation
Journal name Frontiers in Immunology   Check publisher's open access policy
ISSN 1664-3224
Publication date 2016-04-15
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fimmu.2016.00144
Open Access Status DOI
Volume 7
Total pages 8
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2017
Language eng
Abstract Natural killer (NK) cells are the first lymphocyte population to reconstitute following allogeneic hematopoietic stem cell transplantation (HSCT) and are important in mediating immunity against both leukemia and pathogens. Although NK cell numbers generally reconstitute within a month, the acquisition of mature NK cell phenotype and full functional competency can take 6 months or more, and is influenced by graft composition, concurrent pharmacologic immunosuppression, graft-versus-host disease, and other clinical factors. In addition, cytomegalovirus infection and reactivation have a dominant effect on NK cell memory imprinting following allogeneic HSCT just as it does in healthy individuals. Our understanding of NK cell education and licensing has evolved in the years since the "missing self" hypothesis for NK-mediated graft-versus-leukemia effect was first put forward. For example, we now know that NK cell "re-education" can occur, and that unlicensed NK cells can be more protective than licensed NK cells in certain settings, thus raising new questions about how best to harness graft-versus-leukemia effect. Here, we review current understanding of the functional reconstitution of NK cells and NK cell education following allogeneic HSCT, highlighting a conceptual framework for future research
Keyword NK cell
Allogeneic HSCT
NK cell education
Memory NK cell
Cytomegalovirus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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