Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus

Marasini, Nirmal, Giddam, Ashwini K., Ghaffar, Khairunnisa A., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016) Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus. Nanomedicine, 11 10: 1223-1236. doi:10.2217/nnm.16.36


Author Marasini, Nirmal
Giddam, Ashwini K.
Ghaffar, Khairunnisa A.
Batzloff, Michael R.
Good, Michael F.
Skwarczynski, Mariusz
Toth, Istvan
Title Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus
Formatted title
Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1748-6963
1743-5889
Publication date 2016-04-14
Sub-type Article (original research)
DOI 10.2217/nnm.16.36
Open Access Status Not Open Access
Volume 11
Issue 10
Start page 1223
End page 1236
Total pages 14
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2017
Language eng
Formatted abstract
Aim: To develop an oral nanovaccine delivery system for lipopeptide-based vaccine candidate against group A Streptococcus.

Materials & methods: Lipid-core peptide-1-loaded nanoliposomes were prepared as a template and coated with opposite-charged polyelectrolytes to produce particles with size <200 nm. Efficacy of this oral nanovaccine delivery system was evaluated in mice model.

Results: Polymer-coated liposomes produced significantly higher antigen-specific mucosal IgA and systemic IgG titers in comparison to vaccine formulated with a strong mucosal adjuvant upon oral immunization in mice. Moreover, high levels of systemic antibody titers were retained even at day 185 postprimary immunization.

Conclusion: Efficient oral delivery platform for lipopeptide-based vaccines has been developed
Keyword Group A Streptococcus
Lipid-core peptide
Liposomes
Mucosal immunology
Nanoparticles
Oral delivery
Peptides
Vaccines
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Fri, 06 May 2016, 09:45:15 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences