Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

Seow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y. and Farilie, David P. (2016) Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Scientific Reports, 6 24575.1-24575.12. doi:10.1038/srep24575


Author Seow, Vernon
Lim, Junxian
Cotterell, Adam J.
Yau, Mei-Kwan
Xu, Weijun
Lohman, Rink-Jan
Kok, W. Mei
Stoermer, Martin J.
Sweet, Matthew J.
Reid, Robert C.
Suen, Jacky Y.
Farilie, David P.
Title Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2016-04-20
Sub-type Article (original research)
DOI 10.1038/srep24575
Open Access Status DOI
Volume 6
Start page 24575.1
End page 24575.12
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing
Collection year 2017
Language eng
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 03 May 2016, 13:57:28 EST by Dr Rink-jan Lohman on behalf of Institute for Molecular Bioscience