Cisplatin versus carboplatin: comparative review of therapeutic management in solid malignancies

Ho, Gwo Yaw, Woodward, Natasha and Coward, Jermaine I.G. (2016) Cisplatin versus carboplatin: comparative review of therapeutic management in solid malignancies. Critical Reviews in Oncology/Hematology, 102 37-46. doi:10.1016/j.critrevonc.2016.03.014


Author Ho, Gwo Yaw
Woodward, Natasha
Coward, Jermaine I.G.
Title Cisplatin versus carboplatin: comparative review of therapeutic management in solid malignancies
Journal name Critical Reviews in Oncology/Hematology   Check publisher's open access policy
ISSN 1879-0461
1040-8428
Publication date 2016-06
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.critrevonc.2016.03.014
Open Access Status Not Open Access
Volume 102
Start page 37
End page 46
Total pages 10
Place of publication Shannon, Clare Ireland
Publisher Elsevier Ireland
Collection year 2017
Language eng
Abstract The platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladder cancer. Although the final mechanism of inducing tumour cell apoptosis is similar for both compounds, cisplatin has been shown to be more effective in treating specific tumour types. Whilst more favourable toxicity profiles are often associated with carboplatin, this can frequently translate to inferior response in certain malignancies. This review succinctly collates the evidence for the preferential use of these platinum analogues in particular settings in addition to the long-standing dilemma surrounding the paucity of biomarkers predicting response to these agents.
Keyword Carboplatin
Cisplatin
Platinum resistance
Platinum sensitivity
Platinum-based chemotherapy
Radio-sensitisation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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