Insight into the epidemiology of cutaneous squamous cell carcinoma with perineural spread

Warren, Timothy A., Whiteman, David C., Porceddu, Sandro V. and Panizza, Benedict J. (2016) Insight into the epidemiology of cutaneous squamous cell carcinoma with perineural spread. Head and Neck, . doi:10.1002/hed.24453


Author Warren, Timothy A.
Whiteman, David C.
Porceddu, Sandro V.
Panizza, Benedict J.
Title Insight into the epidemiology of cutaneous squamous cell carcinoma with perineural spread
Journal name Head and Neck   Check publisher's open access policy
ISSN 1097-0347
1043-3074
Publication date 2016-04-04
Year available 2016
Sub-type Article (original research)
DOI 10.1002/hed.24453
Open Access Status Not Open Access
Total pages 5
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2017
Language eng
Formatted abstract
Background: Perineural spread (PNS) of cutaneous squamous cell carcinoma of the head and neck (SCCHN) can be associated with poor outcomes. Disease understanding and awareness is limited leading to delayed diagnosis and treatment. The purpose of this study was to identify epidemiological features of patients with PNS of cutaneous SCCHN.

Methods: Tumor characteristics and demographics of patients with PNS of cutaneous SCCHN managed through a single institution were collected between 1998 and 2013.

Results: One hundred twenty patients were included in this study. The majority had a history of skin cancer (85.8%). The median time from primary tumor treatment to PNS symptom onset was 16 months (range, 1-86 months). A total of 34.2% had no perineural invasion (PNI) detected in the primary, and 22.5% had no known primary tumor. Only 5.8% of the patients had nodal involvement at presentation.

Conclusion: Patients can present with PNS from cutaneous SCCHN with no known primary tumor or with primary tumors without PNI. The majority of patients presented without regional nodal involvement.
Keyword Head and neck cancer
Perineural invasion
Skin cancer
Skull base surgery
Squamous cell carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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