Detection of recently discovered human polyomaviruses in a longitudinal kidney transplant cohort

Bialasiewicz, S., Rockett, R. J., Barraclough, K. A., Leary, D., Dudley, K. J., Isbel, N. M. and Sloots, T. P. (2016) Detection of recently discovered human polyomaviruses in a longitudinal kidney transplant cohort. American Journal of Transplantation, . doi:10.1111/ajt.13799


Author Bialasiewicz, S.
Rockett, R. J.
Barraclough, K. A.
Leary, D.
Dudley, K. J.
Isbel, N. M.
Sloots, T. P.
Title Detection of recently discovered human polyomaviruses in a longitudinal kidney transplant cohort
Journal name American Journal of Transplantation   Check publisher's open access policy
ISSN 1600-6143
1600-6135
Publication date 2016-04-19
Year available 2016
Sub-type Article (original research)
DOI 10.1111/ajt.13799
Open Access Status Not Open Access
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Abstract A large number of human polyomaviruses have been discovered in the last 7 years. However, little is known about the clinical impact on vulnerable immunosuppressed patient populations. Blood, urine, and respiratory swabs collected from a prospective, longitudinal adult kidney transplant cohort (n = 167) generally pre-operatively, at day 4, months 1, 3, and 6 posttransplant, and at BK viremic episodes within the first year were screened for 12 human polyomaviruses using real-time polymerase chain reaction. Newly discovered polyomaviruses were most commonly detected in the respiratory tract, with persistent shedding seen for up to 6 months posttransplant. Merkel cell polyomavirus was the most common detection, but was not associated with clinical symptoms or subsequent development of skin cancer or other skin abnormalities. In contrast, KI polyomavirus was associated with respiratory disease in a subset of patients. Human polyomavirus 9, Malawi polyomavirus, and human polyomavirus 12 were not detected in any patient samples.
Keyword Human polyomaviruses
BKPyV
JCPyV
Kidney transplantation
KTx
Merkel cell polyomavirus
MWPyV
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Child Health Research Centre Publications
 
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