Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland, Australia

Emmett, Sarah, Jenkins, Glenn, Boros, Samuel, Whiteman, David C., Panizza, Benedict and Antonsson, Annika (2016) Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland, Australia. ANZ Journal of Surgery, . doi:10.1111/ans.13607


Author Emmett, Sarah
Jenkins, Glenn
Boros, Samuel
Whiteman, David C.
Panizza, Benedict
Antonsson, Annika
Title Low prevalence of human papillomavirus in oral cavity squamous cell carcinoma in Queensland, Australia
Journal name ANZ Journal of Surgery   Check publisher's open access policy
ISSN 1445-2197
1445-1433
Publication date 2016-04-18
Year available 2016
Sub-type Article (original research)
DOI 10.1111/ans.13607
Open Access Status Not Open Access
Total pages 6
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2017
Language eng
Formatted abstract
Background: While human papillomavirus (HPV) is an accepted risk factor for oropharyngeal squamous cell carcinoma (SCC), its aetiological role in oral cavity SCC remains unclear. This study aimed to determine the HPV prevalence in an Australian population.

Methods: DNA was extracted from 63 formalin-fixed paraffin-embedded tumour specimens histologically confirmed as SCC of the oral cavity, diagnosed during 2006-2012. Clinical data were extracted from medical records. HPV presence was determined by polymerase chain reaction. Positive samples were typed by sequencing. Immunohistochemistry was used to assess p16INK4A , p53, pRB, Ki67, Cyclin D1 and p21WAF1 expression.

Results: Five of the 63 tumours (8%) were positive for HPV DNA (three HPV-16 positive and two HPV-18 positive). Two tumours overexpressed p16INK4A (3%) and one of these was also HPV positive. Overexpression of Cyclin D1 correlated significantly with tumour recurrence (P=0.029) and death (P=0.002).

Conclusions: This study has identified a low prevalence of high-risk HPV in Queensland, Australia.
Keyword SCC
Human papillomavirus
Oral cavity
P16
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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