Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers

Martensson, Anders, Greiff, Lennart, Lamei, Sepideh S., Lindstedt, Malin, Olofsson, Tobias C., Vasquez, Alejandra and Cervin, Anders (2016) Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers. International Forum of Allergy and Rhinology, 6 9: 956-963. doi:10.1002/alr.21762

Author Martensson, Anders
Greiff, Lennart
Lamei, Sepideh S.
Lindstedt, Malin
Olofsson, Tobias C.
Vasquez, Alejandra
Cervin, Anders
Title Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers
Journal name International Forum of Allergy and Rhinology   Check publisher's open access policy
ISSN 2042-6984
Publication date 2016-04-15
Year available 2016
Sub-type Article (original research)
DOI 10.1002/alr.21762
Open Access Status Not Open Access
Volume 6
Issue 9
Start page 956
End page 963
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2017
Language eng
Formatted abstract
Background: Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response.

Methods: Twenty-two healthy subjects received a single administration of honeybee LAB in a sham-controlled, double-blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids.

Results: The honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), monokine induced by interferon-γ (MIG), interleukin-15 (IL-15), epidermal growth factor (EGF), eotaxin, interferon gamma-induced protein-10 (IP-10), and interleukin-1 receptor antagonist (IL-1RA).

Conclusion: A single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.
Keyword Bacterial interference
Paranasal sinuses
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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