Role of feline immunodeficiency virus in lymphomagenesis-Going alone or colluding?

Kaye, Sarah, Wang, Wenqi, Miller, Craig, McLuckie, Alicia, Beatty, Julia A., Grant, Chris K., VandeWoude, Sue and Bielefeldt-Ohmann, Helle (2016) Role of feline immunodeficiency virus in lymphomagenesis-Going alone or colluding?. ILAR Journal, 57 1: 24-33. doi:10.1093/ilar/ilv047


Author Kaye, Sarah
Wang, Wenqi
Miller, Craig
McLuckie, Alicia
Beatty, Julia A.
Grant, Chris K.
VandeWoude, Sue
Bielefeldt-Ohmann, Helle
Title Role of feline immunodeficiency virus in lymphomagenesis-Going alone or colluding?
Journal name ILAR Journal   Check publisher's open access policy
ISSN 1930-6180
1084-2020
Publication date 2016-03-31
Year available 2016
Sub-type Article (original research)
DOI 10.1093/ilar/ilv047
Open Access Status Not Open Access
Volume 57
Issue 1
Start page 24
End page 33
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2017
Language eng
Abstract Feline immunodeficiency virus (FIV) is a naturally occurring lentivirus of domestic and nondomestic feline species. Infection in domestic cats leads to immune dysfunction via mechanisms similar to those caused by human immunodeficiency virus (HIV) and, as such, is a valuable natural animal model for acquired immunodeficiency syndrome (AIDS) in humans. An association between FIV and an increased incidence of neoplasia has long been recognized, with frequencies of up to 20% in FIV-positive cats recorded in some studies. This is similar to the rate of neoplasia seen in HIV-positive individuals, and in both species neoplasia typically requires several years to arise. The most frequently reported type of neoplasia associated with FIV infection is lymphoma. Here we review the possible mechanisms involved in FIV lymphomagenesis, including the possible involvement of coinfections, notably those with gamma-herpesviruses.
Keyword Cat
Feline immunodeficiency virus (FIV)
Feline leukemia virus (FeLV)
Gamma-herpesvirus
Human immunodeficiency virus (HIV) model
Lymphoma
Lymphomagenesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
School of Veterinary Science Publications
 
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