Aging-related dysfunction of striatal cholinergic interneurons produces conflict in action selection

Matamales, Miriam, Skrbis, Zala, Hatch, Robert J., Balleine, Bernard W., Gotz, Jurgen and Bertran-Gonzalez, Jesus (2016) Aging-related dysfunction of striatal cholinergic interneurons produces conflict in action selection. Neuron, 90 2: 362-373. doi:10.1016/j.neuron.2016.03.006


Author Matamales, Miriam
Skrbis, Zala
Hatch, Robert J.
Balleine, Bernard W.
Gotz, Jurgen
Bertran-Gonzalez, Jesus
Title Aging-related dysfunction of striatal cholinergic interneurons produces conflict in action selection
Journal name Neuron   Check publisher's open access policy
ISSN 1097-4199
Publication date 2016-04-20
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.neuron.2016.03.006
Open Access Status Not Open Access
Volume 90
Issue 2
Start page 362
End page 373
Total pages 12
Place of publication Cambridge, MA United States
Publisher Cell Press
Collection year 2017
Language eng
Abstract For goal-directed action to remain adaptive, new strategies are required to accommodate environmental changes, a process for which parafascicular thalamic modulation of cholinergic interneurons in the striatum (PF-to-CIN) appears critical. In the elderly, however, previously acquired experience frequently interferes with new learning, yet the source of this effect has remained unexplored. Here, combining sophisticated behavioral designs, cell-specific manipulation, and extensive neuronal imaging, we investigated the involvement of the PF-to-CIN pathway in this process. We found functional alterations of this circuit in aged mice that were consistent with their incapacity to update initial goal-directed learning, resulting in faulty activation of projection neurons in the striatum. Toxicogenetic ablation of CINs in young mice reproduced these behavioral and neuronal defects, suggesting that age-related deficits in PF-to-CIN function reduce the ability of older individuals to resolve conflict between actions, likely contributing to impairments in adaptive goal-directed action and executive control in aging.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Tue, 03 May 2016, 10:31:22 EST by System User on behalf of Clem Jones Centre for Ageing Dementia Research