Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn

Moniruzzaman, Md., Hossain, Md. Sarwar and Bhattacharjee, Partha Sharoti (2016) Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn. Journal of Ethnopharmacology, 186 205-208. doi:10.1016/j.jep.2016.04.008


Author Moniruzzaman, Md.
Hossain, Md. Sarwar
Bhattacharjee, Partha Sharoti
Title Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn
Formatted title
Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn
Journal name Journal of Ethnopharmacology   Check publisher's open access policy
ISSN 1872-7573
0378-8741
Publication date 2016-06-20
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jep.2016.04.008
Open Access Status Not Open Access
Volume 186
Start page 205
End page 208
Total pages 4
Place of publication Shannon, Clare Ireland
Publisher Elsevier Ireland
Collection year 2017
Language eng
Formatted abstract
Ethnapharmacological relevance

Stephania japonica is a common plant, widely distributed in all over Bangladesh. Traditionally, this plant is considered as one of the important ingredients in treatment of a variety of ailments including inflammation, pain, rheumatism, cancer, bone fracture, fever etc. However, the scientific reports regarding the antinociceptive effect of this plant are very limited. This study evaluated the antinociceptive effect of methanolic extract of S. japonica (MESJ) leaves.

Materials and methods

The antinociceptive effect of MESJ was investigated using both heat- and chemical-induced nociceptive models such as hot plate, tail immersion, acetic acid-induced writhing, formalin and glutamate tests at the doses of 50, 100 and 200 mg/kg. Morphine (5 mg/kg) and diclofenac sodium (10 mg/kg) were used as reference drugs in thermal and chemical models, respectively. Moreover, naloxone (2 mg/kg) was used in the thermal models to justify the possible role of the opioid receptors.

Results

MESJ produced a significant and dose-dependent increase in the hot plate and tail immersion latencies which were reversed by the treatment with naloxone, suggests the possible involvement of opioid receptors in this activity. Moreover, MESJ inhibited acetic acid-induced writhing, formalin and glutamate-induced lickings in a dose-dependent manner. In parallel, the reference drugs also produced desired antinociceptive effects in this study.

Conclusion

These results strongly support the antinociceptive activity of the leaves of Stephania japonica and rationalize the traditional use of the leaves in treatment of different painful conditions.
Keyword Stephania japonica
Menisperaceae
Antinociceptive
Medicinal plant
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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