A Randomized Controlled Trial of Two Different Macronutrient Profiles on Weight, Body Composition and Metabolic Parameters in Obese Adolescents Seeking Weight Loss

Truby, Helen, Baxter, Kimberley, Ware, Robert S., Jensen, Diane E., Cardinal, John W., Warren, Janet M., Daniels, Lynne, Davies, Peter S. W., Barrett, Paula, Blumfield, Michelle L. and Batch, Jennifer A. (2016) A Randomized Controlled Trial of Two Different Macronutrient Profiles on Weight, Body Composition and Metabolic Parameters in Obese Adolescents Seeking Weight Loss. Plos One, 11 3: . doi:10.1371/journal.pone.0151787


Author Truby, Helen
Baxter, Kimberley
Ware, Robert S.
Jensen, Diane E.
Cardinal, John W.
Warren, Janet M.
Daniels, Lynne
Davies, Peter S. W.
Barrett, Paula
Blumfield, Michelle L.
Batch, Jennifer A.
Title A Randomized Controlled Trial of Two Different Macronutrient Profiles on Weight, Body Composition and Metabolic Parameters in Obese Adolescents Seeking Weight Loss
Journal name Plos One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-03
Sub-type Article (original research)
DOI 10.1371/journal.pone.0151787
Open Access Status DOI
Volume 11
Issue 3
Total pages 16
Place of publication San Francisco, United States
Publisher Public Library of Science
Collection year 2017
Language eng
Formatted abstract
Objective
Adolescent obesity is difficult to treat and the optimal dietary pattern, particularly in relation to macronutrient composition, remains controversial. This study tested the effect of two structured diets with differing macronutrient composition versus control, on weight, body composition and metabolic parameters in obese adolescents.

Design
A randomized controlled trial conducted in a children’s hospital.

Methods
Eighty seven obese youth (means: age 13.6 years, BMI z-score 2.2, waist: height ratio 0.65, 69% female) completed a psychological preparedness program and were then randomized to a short term ‘structured modified carbohydrate’ (SMC, 35% carbohydrate; 30% protein; 35% fat, n = 37) or a ‘structured low fat’ (SLF, 55% carbohydrate; 20% protein; 25% fat, n = 36) or a wait listed control group (n = 14). Anthropometric, body composition and biochemical parameters were measured at randomization and after 12 weeks, and analyzed under the intention to treat principle using analysis of variance models.

Results
After 12 weeks, data was collected from 79 (91%) participants. BMI z-scores were significantly lower in both intervention groups compared to control after adjusting for baseline values, SLF vs. control, mean difference = -0.13 (95%CI = -0.18, -0.07), P<0.001; SMC vs. control, -0.14 (-0.19, -0.09), P<0.001, but there was no difference between the two intervention diet groups: SLF vs. SMC, 0.00 (-0.05, 0.04), P = 0.83.

Conclusions
Both dietary patterns resulted in similar changes in weight, body composition and metabolic improvements compared to control. The use of a structured eating system which allows flexibility but limited choices can assist in weight change and the rigid application of a low fat eating pattern is not exclusive in its efficacy.

Trial Registration
International Clinical Trials Registry ISRCTN49438757
Keyword Mass Index
Physical-Activities
Carbohydrate
Diet
Children
Health
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
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