Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

Fan, Qiao, Verhoeven, Virginie J. M., Wojciechowski, Robert, Barathi, Veluchamy A., Hysi, Pirro G., Guggenheim, Jeremy A., Hoehn, Rene, Vitart, Veronique, Khawaja, Anthony P., Yamashiro, Kenji, Hosseini, S. Mohsen, Lehtimaki, Terho, Lu, Yi, Haller, Toomas, Xie, Jing, Delcourt, Cecile, Pirastu, Mario, Wedenoja, Juho, Gharahkhani, Puya, Venturini, Cristina, Miyake, Masahiro, Hewitt, Alex W., Guo, Xiaobo, Mazur, Johanna, Huffman, Jenifer E., Williams, Katie M., Polasek, Ozren, Campbell, Harry, Rudan, Igor, Vatavuk, Zoran, Wilson, James F., Joshi, Peter K., McMahon, George, St Pourcain, Beate, Evans, David M., Simpson, Claire L., Schwantes-An, Tae-Hwi, Igo, Robert P., Mirshahi, Alireza, Cougnard-Gregoire, Audrey, Bellenguez, Celine, Blettner, Maria, Raitakari, Olli, Kaehoenen, Mika, Seppala, Ilkka, Zeller, Tanja, Meitinger, Thomas, Ried, Janina S., Gieger, Christian, Portas, Laura, van Leeuwen, Elisabeth M., Amin, Najaf, Uitterlinden, Andre G., Rivadeneira, Fernando, Hofman, Albert, Vingerling, Johannes R., Wang, Ya Xing, Wang, Xu, Boh, Eileen Tai-Hui, Ikram, M. Kamran, Sabanayagam, Charumathi, Gupta, Preeti, Tan, Vincent, Zhou, Lei, Ho, Candice E. H., Lim, Wan'e, Beuerman, Roger W., Siantar, Rosalynn, Tai, E-Shyong, Vithana, Eranga, Mihailov, Evelin, Khor, Chiea-Chuen, Hayward, Caroline, Luben, Robert N., Foster, Paul J., Klein, Barbara E. K., Klein, Ronald, Wong, Hoi-Suen, Mitchell, Paul, Metspalu, Andres, Aung, Tin, Young, Terri L., He, Mingguang, Paerssinen, Olavi, van Duijn, Cornelia M., Wang, Jie Jin, Williams, Cathy, Jonas, Jost B., Teo, Yik-Ying, David, A. Mackey M., Oexle, Konrad, Yoshimura, Nagahisa, Paterson, Andrew D., Pfeiffer, Norbert, Wong, Tien-Yin, Baird, Paul N., Stambolian, Dwight, Bailey-Wilson, Joan E., Cheng, Ching-Yu, Hammond, Christopher J., Klaver, Caroline C. W., Saw, Seang-Mei, Rahi, Jugnoo S., Korobelnik, Jean-Francois, Kemp, John P., Timpson, Nicholas J., Smith, George Davey, Craig, Jamie E., Burdon, Kathryn P., Fogarty, Rhys D., Iyengar, Sudha K., Chew, Emily, Janmahasatian, Sarayut, Martin, Nicholas G., MacGregor, Stuart, Xu, Liang, Schache, Maria, Nangia, Vinay, Panda-Jonas, Songhomitra, Wright, Alan F., Fondran, Jeremy R., Lass, Jonathan H., Feng, Sheng, Zhao, Jing Hua, Khaw, Kay-Tee, Wareham, Nick J., Rantanen, Taina, Kaprio, Jaakko, Pang, Chi Pui, Chen, Li Jia, Tam, Pancy O., Jhanji, Vishal, Young, Alvin L., Doering, Angela, Raffel, Leslie J., Cotch, Mary-Frances, Li, Xiaohui, Yip, Shea Ping, Yap, Maurice K. H., Biino, Ginevra, Vaccargiu, Simona, Fossarello, Maurizio, Fleck, Brian, Yazar, Seyhan, Tideman, Jan Willem L., Tedja, Milly, Deangelis, Margaret M., Morrison, Margaux, Farrer, Lindsay, Zhou, Xiangtian, Chen, Wei, Mizuki, Nobuhisa, Meguro, Akira and Makela, Kari Matti (2016) Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nature Communications, 7 . doi:10.1038/ncomms11008


Author Fan, Qiao
Verhoeven, Virginie J. M.
Wojciechowski, Robert
Barathi, Veluchamy A.
Hysi, Pirro G.
Guggenheim, Jeremy A.
Hoehn, Rene
Vitart, Veronique
Khawaja, Anthony P.
Yamashiro, Kenji
Hosseini, S. Mohsen
Lehtimaki, Terho
Lu, Yi
Haller, Toomas
Xie, Jing
Delcourt, Cecile
Pirastu, Mario
Wedenoja, Juho
Gharahkhani, Puya
Venturini, Cristina
Miyake, Masahiro
Hewitt, Alex W.
Guo, Xiaobo
Mazur, Johanna
Huffman, Jenifer E.
Williams, Katie M.
Polasek, Ozren
Campbell, Harry
Rudan, Igor
Vatavuk, Zoran
Wilson, James F.
Joshi, Peter K.
McMahon, George
St Pourcain, Beate
Evans, David M.
Simpson, Claire L.
Schwantes-An, Tae-Hwi
Igo, Robert P.
Mirshahi, Alireza
Cougnard-Gregoire, Audrey
Bellenguez, Celine
Blettner, Maria
Raitakari, Olli
Kaehoenen, Mika
Seppala, Ilkka
Zeller, Tanja
Meitinger, Thomas
Ried, Janina S.
Gieger, Christian
Portas, Laura
van Leeuwen, Elisabeth M.
Amin, Najaf
Uitterlinden, Andre G.
Rivadeneira, Fernando
Hofman, Albert
Vingerling, Johannes R.
Wang, Ya Xing
Wang, Xu
Boh, Eileen Tai-Hui
Ikram, M. Kamran
Sabanayagam, Charumathi
Gupta, Preeti
Tan, Vincent
Zhou, Lei
Ho, Candice E. H.
Lim, Wan'e
Beuerman, Roger W.
Siantar, Rosalynn
Tai, E-Shyong
Vithana, Eranga
Mihailov, Evelin
Khor, Chiea-Chuen
Hayward, Caroline
Luben, Robert N.
Foster, Paul J.
Klein, Barbara E. K.
Klein, Ronald
Wong, Hoi-Suen
Mitchell, Paul
Metspalu, Andres
Aung, Tin
Young, Terri L.
He, Mingguang
Paerssinen, Olavi
van Duijn, Cornelia M.
Wang, Jie Jin
Williams, Cathy
Jonas, Jost B.
Teo, Yik-Ying
David, A. Mackey M.
Oexle, Konrad
Yoshimura, Nagahisa
Paterson, Andrew D.
Pfeiffer, Norbert
Wong, Tien-Yin
Baird, Paul N.
Stambolian, Dwight
Bailey-Wilson, Joan E.
Cheng, Ching-Yu
Hammond, Christopher J.
Klaver, Caroline C. W.
Saw, Seang-Mei
Rahi, Jugnoo S.
Korobelnik, Jean-Francois
Kemp, John P.
Timpson, Nicholas J.
Smith, George Davey
Craig, Jamie E.
Burdon, Kathryn P.
Fogarty, Rhys D.
Iyengar, Sudha K.
Chew, Emily
Janmahasatian, Sarayut
Martin, Nicholas G.
MacGregor, Stuart
Xu, Liang
Schache, Maria
Nangia, Vinay
Panda-Jonas, Songhomitra
Wright, Alan F.
Fondran, Jeremy R.
Lass, Jonathan H.
Feng, Sheng
Zhao, Jing Hua
Khaw, Kay-Tee
Wareham, Nick J.
Rantanen, Taina
Kaprio, Jaakko
Pang, Chi Pui
Chen, Li Jia
Tam, Pancy O.
Jhanji, Vishal
Young, Alvin L.
Doering, Angela
Raffel, Leslie J.
Cotch, Mary-Frances
Li, Xiaohui
Yip, Shea Ping
Yap, Maurice K. H.
Biino, Ginevra
Vaccargiu, Simona
Fossarello, Maurizio
Fleck, Brian
Yazar, Seyhan
Tideman, Jan Willem L.
Tedja, Milly
Deangelis, Margaret M.
Morrison, Margaux
Farrer, Lindsay
Zhou, Xiangtian
Chen, Wei
Mizuki, Nobuhisa
Meguro, Akira
Makela, Kari Matti
Title Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2016-04-06
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ncomms11008
Open Access Status DOI
Volume 7
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
Keyword Myopia
Human eye disorder
Public health challenge
Heterogeneity of myopia
Gene and environment interactions
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
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