Intravesical onabotulinumtoxinA injection for overactive orthotopic ileal neobladder: feasibility and efficacy

Hoag, Nathan, Tse, Vincent, Wang, Audrey, Chung, Eric and Gani, Johan (2016) Intravesical onabotulinumtoxinA injection for overactive orthotopic ileal neobladder: feasibility and efficacy. International Neurourology Journal, 20 1: 81-85. doi:10.5213/inj.1630380.190


Author Hoag, Nathan
Tse, Vincent
Wang, Audrey
Chung, Eric
Gani, Johan
Title Intravesical onabotulinumtoxinA injection for overactive orthotopic ileal neobladder: feasibility and efficacy
Journal name International Neurourology Journal   Check publisher's open access policy
ISSN 2093-6931
2093-4777
Publication date 2016-03-01
Year available 2016
Sub-type Article (original research)
DOI 10.5213/inj.1630380.190
Open Access Status DOI
Volume 20
Issue 1
Start page 81
End page 85
Total pages 5
Place of publication Suwon, Korea, Republic of
Publisher Korean Continence Society
Collection year 2017
Language eng
Abstract The efficacy of intravesical onabotulinumtoxinA (BTXA) in the treatment of overactive bladder (OAB) has been well documented. The use of BTXA injection in orthotopic neobladders is yet to be studied. We present 4 cases of patients injected with intravesical BTXA for overactive orthotopic ileal neobladder. We recorded patient demographics, presenting and follow-up symptoms, urodynamic profiles, and Patient Global Impression of Improvement (PGI-I) scores. The 4 patients reported varying degrees of subjective improvements in the symptoms, including urgency, urge incontinence, and pad usage. Mean followup duration was 8.3 months (range, 5-14 months). Average PGI-I score was 3 ("a little better") (range, 2-4). To our knowledge, the current study is the first case series examining BTXA injection for orthotopic neobladder overactivity. BTXA injection yielded varying degrees of objective and subjective improvements, without significant complications. Intravesical BTXA injection is feasible and may be considered as a potential treatment alternative for OAB in orthotopic neobladders, although further study is warranted.
Keyword Administration
Continent
Intravesical
OnabotulinumtoxinA
Overactive
Urinary bladder
Urinary diversion
Urinary reservoirs
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Sub-type: Article (original research)
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