Medulloblastoma growth inhibition by Hedgehog pathway blockade

Berman, David M., Karhadkar, Sunil S., Hallahan, Andrew R., Pritchard, Joel I., Eberhart, Charles G., Watkins, D. Neil, Chen, James K., Cooper, Michael K., Taipale, Jussi, Olson, James M. and Beachy, Philip A. (2002) Medulloblastoma growth inhibition by Hedgehog pathway blockade. Science, 297 5586: 1559-1561. doi:10.1126/science.1073733


Author Berman, David M.
Karhadkar, Sunil S.
Hallahan, Andrew R.
Pritchard, Joel I.
Eberhart, Charles G.
Watkins, D. Neil
Chen, James K.
Cooper, Michael K.
Taipale, Jussi
Olson, James M.
Beachy, Philip A.
Title Medulloblastoma growth inhibition by Hedgehog pathway blockade
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2002-08-30
Sub-type Article (original research)
DOI 10.1126/science.1073733
Open Access Status Not yet assessed
Volume 297
Issue 5586
Start page 1559
End page 1561
Total pages 3
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Abstract Constitutive Hedgehog (Hh) pathway activity is associated with initiation of neoplasia, but its role in the continued growth of established tumors is unclear. Here, we investigate the therapeutic efficacy of the Hh pathway antagonist cyclopamine in preclinical models of medulloblastoma, the most common malignant brain tumor in children. Cyclopamine treatment of murine medulloblastoma cells blocked proliferation in vitro and induced changes in gene expression consistent with initiation of neuronal differentiation and loss of neuronal stem cell-like character. This compound also caused regression of murine tumor allografts in vivo and induced rapid death of cells from freshly resected human medulloblastomas, but not from other brain tumors, thus establishing a specific role for Hh pathway activity in medulloblastoma growth.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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