Molecular mechanisms influencing NK cell development: implications for NK cell malignancies.

Mujaj, Sally A., Spanevello, Michelle M., Gandhi, Maher K. and Nourse, Jamie P. (2011) Molecular mechanisms influencing NK cell development: implications for NK cell malignancies.. American Journal of Blood Research, 1 1: 34-45.

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Author Mujaj, Sally A.
Spanevello, Michelle M.
Gandhi, Maher K.
Nourse, Jamie P.
Title Molecular mechanisms influencing NK cell development: implications for NK cell malignancies.
Journal name American Journal of Blood Research   Check publisher's open access policy
ISSN 2160-1992
Publication date 2011-05-22
Sub-type Critical review of research, literature review, critical commentary
Open Access Status File (Publisher version)
Volume 1
Issue 1
Start page 34
End page 45
Total pages 12
Place of publication Madison, WI United States
Publisher E-Century Publishing Corporation
Language eng
Abstract Natural Killer (NK) cells are important effector cells in both the innate and adaptive immune responses. Although they were identified almost 40 years ago, our understanding of how and where NK cells develop is rudimentary. In particular, we have only a limited understanding of the signaling pathways that need to be activated to cause NK cell commitment and maturation. Knowledge of this process is important as disruptions can lead to the development of highly aggressive NK cell malignancies. In this review, we discuss the known molecular mechanisms that trigger NK cell commitment, prompt them to mature and finally allow them to become functional killers. Known disruptions in this developmental process, and how they may contribute to malignancy, are also addressed. (AJBR1105001).
Keyword Animal
Human
Natural Killer cell
Transcription factors
Cytokines
Cell differentiation
Lymphopoiesis
Gene expression regulation
Lymphoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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Created: Fri, 29 Apr 2016, 15:57:15 EST by Maher Gandhi on behalf of UQ Diamantina Institute