Application of the multifactor dimensionality reduction method in evaluation of the roles of multiple genes/enzymes in multidrug-resistant acquisition in Pseudomonas aeruginosa strains

Yao, Z., Peng, Y., Bi, J., Xie, C., Chen, X., Li, Y., Ye, X. and Zhou, J. (2016) Application of the multifactor dimensionality reduction method in evaluation of the roles of multiple genes/enzymes in multidrug-resistant acquisition in Pseudomonas aeruginosa strains. Epidemiology and Infection, 144 4: 856-863. doi:10.1017/S0950268815001788


Author Yao, Z.
Peng, Y.
Bi, J.
Xie, C.
Chen, X.
Li, Y.
Ye, X.
Zhou, J.
Title Application of the multifactor dimensionality reduction method in evaluation of the roles of multiple genes/enzymes in multidrug-resistant acquisition in Pseudomonas aeruginosa strains
Journal name Epidemiology and Infection   Check publisher's open access policy
ISSN 1469-4409
0950-2688
Publication date 2016-03
Year available 2015
Sub-type Article (original research)
DOI 10.1017/S0950268815001788
Open Access Status Not Open Access
Volume 144
Issue 4
Start page 856
End page 863
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2017
Formatted abstract
Multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections are major threats to healthcare-associated infection control and the intrinsic molecular mechanisms of MDRPA are also unclear. We examined 348 isolates of P. aeruginosa, including 188 MDRPA and 160 non-MDRPA, obtained from five tertiary-care hospitals in Guangzhou, China. Significant correlations were found between gene/enzyme carriage and increased rates of antimicrobial resistance (P < 0·01). gyrA mutation, OprD loss and metallo-β-lactamase (MBL) presence were identified as crucial molecular risk factors for MDRPA acquisition by a combination of univariate logistic regression and a multifactor dimensionality reduction approach. The MDRPA rate was also elevated with the increase in positive numbers of those three determinants (P < 0·001). Thus, gyrA mutation, OprD loss and MBL presence may serve as predictors for early screening of MDRPA infections in clinical settings.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Fri, 29 Apr 2016, 07:11:29 EST by Yang Peng on behalf of Medicine - Royal Brisbane and Women's Hospital