XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls

Bu, Tao, Liu, Li, Sun, Yong, Zhao, Li, Peng, Yang, Zhou, Shudong, Li, Lixia, Chen, Sidong and Gao, Yanhui (2014) XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls. PLoS One, 9 1: . doi:10.1371/journal.pone.0086086


Author Bu, Tao
Liu, Li
Sun, Yong
Zhao, Li
Peng, Yang
Zhou, Shudong
Li, Lixia
Chen, Sidong
Gao, Yanhui
Title XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls
Formatted title
XRCC1 Arg399Gln polymorphism confers risk of breast cancer in American population: a meta-analysis of 10846 cases and 11723 controls
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-01-28
Sub-type Article (original research)
DOI 10.1371/journal.pone.0086086
Open Access Status DOI
Volume 9
Issue 1
Total pages 9
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background: In the X-ray repair cross-complementing group 1 (XRCC1) gene, a polymorphism, Arg399Gln (rs25487), has been shown to change neoconservative amino acid and thus result in alternation of DNA repair capacity. Numerous studies have investigated the association between Arg399Gln and breast cancer risk in the American population, but yielding inconsistent results. This study aimed to clarify the role of this polymorphism in susceptibility to breast cancer.

Methods: 
Literatures were searched in multiple databases including PubMed, Springer Link, Ovid, EBSCO and ScienceDirect databases up to April 2013. A comprehensive meta-analysis was conducted to estimate the overall odds ratio (OR), by integrating data from 18 case control studies of 10846 cases and 11723 controls in the American population.

Results: 
Overall, significant association was observed between the Arg399Gln polymorphism and breast cancer risk under the random-effects model (OR for dominant model = 1.12, 95% CI: 1.02–1.24, Pheterogeneity = 0.003; OR for additive model = 1.07, 95% CI: 1.01–1.14, Pheterogeneity = 0.017). Further sensitivity analysis supported the robust stability of this current result by showing similar ORs before and after removal of a single study.

Conclusions: This meta-analysis suggests that the XRCC1 Arg399Gln polymorphism may significantly contribute to susceptibility of breast cancer in the American population.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article number e86086

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Fri, 29 Apr 2016, 07:02:30 EST by Yang Peng on behalf of Medicine - Royal Brisbane and Women's Hospital