Multidrug-resistant Pseudomonas aeruginosa infections pose growing threat to health care-associated infection control in the hospitals of Southern China: a case-control surveillance study

Peng, Yang, Bi, Jiaqi, Shi, Jing, Li, Ying, Ye, Xiaohua, Chen, Xiaofeng and Yao, Zhenjiang (2014) Multidrug-resistant Pseudomonas aeruginosa infections pose growing threat to health care-associated infection control in the hospitals of Southern China: a case-control surveillance study. American Journal of Infection Control, 42 12: 1308-1311. doi:10.1016/j.ajic.2014.08.006


Author Peng, Yang
Bi, Jiaqi
Shi, Jing
Li, Ying
Ye, Xiaohua
Chen, Xiaofeng
Yao, Zhenjiang
Title Multidrug-resistant Pseudomonas aeruginosa infections pose growing threat to health care-associated infection control in the hospitals of Southern China: a case-control surveillance study
Formatted title
Multidrug-resistant Pseudomonas aeruginosa infections pose growing threat to health care-associated infection control in the hospitals of Southern China: a case-control surveillance study
Journal name American Journal of Infection Control   Check publisher's open access policy
ISSN 0196-6553
1527-3296
Publication date 2014-12
Sub-type Article (original research)
DOI 10.1016/j.ajic.2014.08.006
Open Access Status Not Open Access
Volume 42
Issue 12
Start page 1308
End page 1311
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Background: Multidrug-resistant Pseudomonas aeruginosa (MDRPA) is one of the most common agents among health care–associated infections. There is a lack of data on the clinical features of MDRPA from Southern China.
Methods: A case-control surveillance study of P aeruginosa was conducted based on surveillance from July 2008-December 2012, in 5 hospitals of Guangzhou, China. Data were analyzed by univariate analysis and multivariate logistic regression using Stata 13 (StataCorp, College Station, TX).
Results: Of the 348 P aeruginosa strains, the prevalence of MDRPA was 54%, and it has increased over time. Isolates of P aeruginosa showed increased resistance to most antimicrobials during this time period. Independent risk factors were tracheal intubation insertion (odds ratio [OR], 2.21; 95% confidence interval [CI], 1.16-4.23; P = .02) and use of carbapenem (odds ratio [OR], 3.36; 95% confidence interval [CI], 1.75-6.47; P < .01). The distribution of MDRPA infections was uneven among the 5 hospitals (P = .01). Being infected with MDRPA strains resulted in longer duration of hospitalization (39 vs 24 days) and higher mortality (49% vs 20%).
Conclusion: The infections of MDRPA were severe issues. More stringent measures should be applied for those with independent predictors of MDRPA infections because they may induce adverse clinical outcomes.
Keyword Multidrug-resistant Pseudomonas aeruginosa
Southern China
Case-control surveillance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 28 Apr 2016, 18:51:11 EST by Yang Peng on behalf of Medicine - Royal Brisbane and Women's Hospital