This thesis investigated the role of trait resilience, perceived control and emotion regulation in the prediction of indicators of strain in order to add to the field of stress research. It was predicted that trait resilience would result in lower levels of strain, and this relationship would be moderated by perceived control, such that high control would strengthen the inverse relationship of resilience with strain. Furthermore, emotion regulation in the form of positive reappraisal and attention deployment was proposed as a potential mediating mechanism in the process. In order to test these predictions, 97 undergraduate psychology students participated in a laboratory experiment, which involved a demanding inbox task that aimed to simulate a work environment. Trait resilience was measured and control was manipulated in order to create variance in the perceptions of control. Throughout the experiment, several indicators of physiological and psychological strain were measured: heart rate variability, cortisol activation, anxiety and calmness. Furthermore, emotion regulation was measured following task completion. Results indicated that trait resilience is related to lower levels of cortisol activation. In addition, when the interaction of perceived control was examined, it was found that high perceived control resulted in highly resilient individuals recording a lower strain response in the form of heart rate variability. The results concerning the role of emotion regulation remained largely inconclusive however did provide preliminary findings for future research. Following explanation and contributions/implications of the findings, limitations and suggestions for future research are outlined.