The impact of lycopene and non-lycopene-containing tomato extracts on in vitro prostate cancer cell growth

O'Donoghue, A., O'Hare, T. J., Zhang, B. and Fanning, K. (2015). The impact of lycopene and non-lycopene-containing tomato extracts on in vitro prostate cancer cell growth. In: XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014): VI International Symposium on Human Health Effects of Fruits and Vegetables (FAVHEALTH 2014). XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014), Brisbane, Australia, (147-152). 17-22 August 2014. doi:10.17660/ActaHortic.2015.1106.23


Author O'Donoghue, A.
O'Hare, T. J.
Zhang, B.
Fanning, K.
Title of paper The impact of lycopene and non-lycopene-containing tomato extracts on in vitro prostate cancer cell growth
Conference name XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014)
Conference location Brisbane, Australia
Conference dates 17-22 August 2014
Convener O'Hare, T. J.
Proceedings title XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014): VI International Symposium on Human Health Effects of Fruits and Vegetables (FAVHEALTH 2014)   Check publisher's open access policy
Journal name Acta Horticulturae   Check publisher's open access policy
Place of Publication Leuven, Belgium
Publisher International Society for Horticultural Science
Publication Year 2015
Sub-type Fully published paper
DOI 10.17660/ActaHortic.2015.1106.23
Open Access Status Not Open Access
ISBN 9789462611009
ISSN 0567-7572
2406-6168
Volume 1106
Start page 147
End page 152
Total pages 6
Chapter number 23
Total chapters 36
Collection year 2016
Language eng
Formatted Abstract/Summary
High tomato diets have been observed to significantly reduce the risk of prostate cancer; however, the causal agents within tomato that produce this effect are uncertain. Lycopene, the principle and highly abundant carotenoid within tomato fruit, has been suggested to be the major causative agent due to its in vitro antioxidant and anti-carcinogenic effects; however, in vivo evidence is inconclusive, with whole tomato supplementation being more protective than pure lycopene. This implicates the involvement of other tomato nutrients and carotenoids in the protective effect. This was investigated by applying hexane extracts of tomatoes with or without all-trans-lycopene as their principal fruit carotenoid, dissolved in tetrahydrofuran to PC3 prostate cancer cells. High performance liquid chromatography and photodiode array analysis verified that orange grape (RO) and tangerine (TAN) tomatoes had almost exclusively β-carotene and tetra-cis-lycopene as their principal carotenoid, respectively. In contrast, red grape (RR), tangerine wild-type (TWT), and commercial truss (TRUSS) tomatoes contained predominantly all-trans-lycopene. An MTT cell inhibition assay revealed that the TAN tomato extract treatment had a barely significant inhibitory effect upon PC3 cells compared with the control, while β-carotene tomato extracts had no significant impact on PC3 proliferation. When the tomato lines with all-trans-lycopene as their predominant carotenoid were pooled, a similar inhibition of prostate cancer cell growth was observed, with a tendency for TAN tomato extract to inhibit growth slightly better. This preliminary study demonstrates that tetra-cis-lycopene as well as all-trans lycopene may both have an anti-carcinogenic effect on prostate cancer cells.
Keyword Carotenoids
PC3
Phytonutrients
Tangerine
Solanum lycopersicum
Cell growth inhibition
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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