Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype

Scott, H. A., Gibson, P. G., Garg, M. L., Upham, J. W. and Wood, L. G. (2016) Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype. Allergy, 71 7: 1037-1047. doi:10.1111/all.12891


Author Scott, H. A.
Gibson, P. G.
Garg, M. L.
Upham, J. W.
Wood, L. G.
Title Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype
Journal name Allergy   Check publisher's open access policy
ISSN 1398-9995
0105-4538
Publication date 2016-07
Year available 2016
Sub-type Article (original research)
DOI 10.1111/all.12891
Open Access Status Not Open Access
Volume 71
Issue 7
Start page 1037
End page 1047
Total pages 11
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Background: Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese-asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with asthma.

Methods: Obese (n = 39) and nonobese (n = 42) females and obese (n = 24) and nonobese (n = 25) males with asthma were recruited. Females were further categorized as reproductive-aged (<50 years old; n = 36) or older (>50 years old; n = 45). Thirteen (36.1%) reproductive-aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers.

Results: Obese reproductive-aged females had higher sputum %neutrophils than nonobese reproductive-aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C-reactive protein and IL-6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive-aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015).

Conclusions: This study suggests that sex hormones and systemic inflammation may be mediating the obese-asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive-aged females warrants further investigation.
Keyword Asthma
Neutrophil
Obesity
Sex hormone
Systemic inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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