A lymphomagenic role for HIV beyond immune suppression?

Dolcetti, Riccardo, Gloghini, Annunziata, Caruso, Arnaldo and Carbone, Antonino (2016) A lymphomagenic role for HIV beyond immune suppression?. Blood, 127 11: 1403-1409. doi:10.1182/blood-2015-11-681411


Author Dolcetti, Riccardo
Gloghini, Annunziata
Caruso, Arnaldo
Carbone, Antonino
Title A lymphomagenic role for HIV beyond immune suppression?
Journal name Blood   Check publisher's open access policy
ISSN 1528-0020
0006-4971
Publication date 2016-03-17
Year available 2016
Sub-type Article (original research)
DOI 10.1182/blood-2015-11-681411
Open Access Status Not yet assessed
Volume 127
Issue 11
Start page 1403
End page 1409
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society of Hematology
Collection year 2017
Language eng
Abstract Despite the immune reconstitution promoted by combined antiretroviral therapy (cART), lymphomas still represent the most common type of cancer in HIVinfected individuals. Cofactors related to immunodeficiency such as oncogenic viruses, chronic antigenic stimulation, and cytokine overproduction are thought to be the main drivers of HIV lymphomagenesis, although the current scenario does not convincingly explain the stillhigh incidence of lymphomas and the occurrence of peculiar lymphoma histotypes in HIV-infected patients under cART. Recent findings are challenging the current view of a mainly indirect role of HIV in lymphoma development and support the possibility that HIV may directly contribute to lymphomagenesis. In fact, mechanisms other than immune suppression involve biologic effects mediated by HIV products that are secreted and accumulate in lymphoid tissues, mainly within lymph node germinal centers. Notably, HIV-infected patients with lymphomas, but not those not affected by these tumors, were recently shown to carry HIV p17 protein variants with enhanced B-cell clonogenic activity. HIV p17 protein variants were characterized by the presence of distinct insertions at the C-terminal region of the protein responsible for a structural destabilization and the acquisition of novel biologic properties. These data are changing the current paradigm assuming that HIV is only indirectly related to lymphomagenesis. Furthermore, these recent findings are consistent with a role of HIV as a critical microenvironmental factor promoting lymphomadevelopment and pave the way for further studies that may lead to the design of more effective strategies for an early identification and improved control of lymphomas in the HIV setting.
Keyword Combined antiretroviral therapy (cART)
Lymphomas
Cancer
HIV-infected individuals
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
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