Glyco-centric lectin magnetic bead array (LeMBA) - proteomics dataset of human serum samples from healthy, Barrett's esophagus and esophageal adenocarcinoma individuals

Shah, Alok K., Le Cao, Kim-Anh, Choi, Eunju, Chen, David, Gautier, Benoit, Nancarrow, Derek, Whiteman, David C., Baker, Peter R., Clauser, Karl R., Chalkley, Robert J., Saunders, Nicholas A., Barbour, Andrew P., Joshi, Virendra and Hill, Michelle M. (2016) Glyco-centric lectin magnetic bead array (LeMBA) - proteomics dataset of human serum samples from healthy, Barrett's esophagus and esophageal adenocarcinoma individuals. Data in Brief, 7 1058-1062. doi:10.1016/j.dib.2016.03.081


Author Shah, Alok K.
Le Cao, Kim-Anh
Choi, Eunju
Chen, David
Gautier, Benoit
Nancarrow, Derek
Whiteman, David C.
Baker, Peter R.
Clauser, Karl R.
Chalkley, Robert J.
Saunders, Nicholas A.
Barbour, Andrew P.
Joshi, Virendra
Hill, Michelle M.
Title Glyco-centric lectin magnetic bead array (LeMBA) - proteomics dataset of human serum samples from healthy, Barrett's esophagus and esophageal adenocarcinoma individuals
Journal name Data in Brief   Check publisher's open access policy
ISSN 2352-3409
Publication date 2016-06-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.dib.2016.03.081
Open Access Status DOI
Volume 7
Start page 1058
End page 1062
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Abstract This data article describes serum glycoprotein biomarker discovery and qualification datasets generated using lectin magnetic bead array (LeMBA) - mass spectrometry techniques, "Serum glycoprotein biomarker discovery and qualification pipeline reveals novel diagnostic biomarker candidates for esophageal adenocarcinoma" [1]. Serum samples collected from healthy, metaplastic Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) individuals were profiled for glycoprotein subsets via differential lectin binding. The biomarker discovery proteomics dataset consisting of 20 individual lectin pull-downs for 29 serum samples with a spiked-in internal standard chicken ovalbumin protein has been deposited in the PRIDE partner repository of the ProteomeXchange Consortium with the data set identifier PRIDE: PXD002442. Annotated MS/MS spectra for the peptide identifications can be viewed using MS-Viewer (〈 http://prospector2.ucsf.edu/prospector/cgi-bin/msform.cgi?form=msviewer〉) using search key "jn7qafftux". The qualification dataset contained 6-lectin pulldown-coupled multiple reaction monitoring-mass spectrometry (MRM-MS) data for 41 protein candidates, from 60 serum samples. This dataset is available as a supplemental files with the original publication [1].
Keyword Barrett's esophagus
Biomarker
Esophageal adenocarcinoma
Glycoprotein
Proteomics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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