Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol

Summerlin, Natalie, Qu, Zhi, Pujara, Naisarg, Sheng, Yong, Jambhrunkar, Siddharth, McGuckin, Michael and Popat, Amirali (2016) Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. Colloids and Surfaces B: Biointerfaces, 144 1-7. doi:10.1016/j.colsurfb.2016.03.076


Author Summerlin, Natalie
Qu, Zhi
Pujara, Naisarg
Sheng, Yong
Jambhrunkar, Siddharth
McGuckin, Michael
Popat, Amirali
Title Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol
Journal name Colloids and Surfaces B: Biointerfaces   Check publisher's open access policy
ISSN 1873-4367
0927-7765
Publication date 2016-08-01
Sub-type Article (original research)
DOI 10.1016/j.colsurfb.2016.03.076
Open Access Status Not Open Access
Volume 144
Start page 1
End page 7
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
The naturally occurring polyphenol resveratrol (RES) has attracted increasing attention in recent years due to its antioxidant, anti-inflammatory, and anticancer activity. However, resveratrol’s promising potential as a nutraceutical is hindered by its poor aqueous solubility, which limits its biological activity. Here we show that encapsulating resveratrol in colloidal mesoporous silica nanoparticles (MCM-48-RES) enhances its saturated solubility by ∼95% and increases its in vitro release kinetics compared to pure resveratrol. MCM-48-RES showed high loading capacity (20% w/w) and excellent encapsulation efficiency (100%). When tested against HT-29 and LS147T colon cancer cell lines, MCM-48-RES-mediated in vitro cell death was higher than that of pure resveratrol, mediated via the PARP and cIAP1 pathways. Finally, MCM-48-RES treatment also inhibited lipopolysaccharide-induced NF-κB activation in RAW264.7 cells, demonstrating improved anti-inflammatory activity. More broadly, our observations demonstrate the potential of colloidal mesoporous silica nanoparticles as next generation delivery carriers for hydrophobic nutraceuticals.
Keyword Anti-inflammatory
Anticancer
Colorectal cancer
Mesoporous silica
Nanoparticles
Resveratrol
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
HERDC Pre-Audit
School of Pharmacy Publications
 
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