Human podocyte depletion in association with older age and hypertension

Puelles, Victor G., Cullen-McEwen, Luise A., Taylor, Georgina E., Li, Jinhua, Hughson, Michael D., Kerr, Peter G., Hoy, Wendy E. and Bertram, John F. (2016) Human podocyte depletion in association with older age and hypertension. American Journal of Physiology-Renal Physiology, 310 7: F656-F668. doi:10.1152/ajprenal.00497.2015


Author Puelles, Victor G.
Cullen-McEwen, Luise A.
Taylor, Georgina E.
Li, Jinhua
Hughson, Michael D.
Kerr, Peter G.
Hoy, Wendy E.
Bertram, John F.
Title Human podocyte depletion in association with older age and hypertension
Journal name American Journal of Physiology-Renal Physiology   Check publisher's open access policy
ISSN 1931-857X
1522-1466
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.1152/ajprenal.00497.2015
Open Access Status Not Open Access
Volume 310
Issue 7
Start page F656
End page F668
Total pages 13
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Collection year 2017
Language eng
Abstract Podocyte depletion plays a major role in the development and progression of glomerulosclerosis. Many kidney diseases are more common in older age and often coexist with hypertension. We hypothesized that podocyte depletion develops in association with older age and is exacerbated by hypertension. Kidneys from 19 adult Caucasian American males without overt renal disease were collected at autopsy in Mississippi. Demographic data were obtained from medical and autopsy records. Subjects were categorized by age and hypertension as potential independent and additive contributors to podocyte depletion. Design-based stereology was used to estimate individual glomerular volume and total podocyte number per glomerulus, which allowed the calculation of podocyte density (number per volume). Podocyte depletion was defined as a reduction in podocyte number (absolute depletion) or podocyte density (relative depletion). The cortical location of glomeruli (outer or inner cortex) and presence of parietal podocytes were also recorded. Older age was an independent contributor to both absolute and relative podocyte depletion, featuring glomerular hypertrophy, podocyte loss, and thus reduced podocyte density. Hypertension was an independent contributor to relative podocyte depletion by exacerbating glomerular hypertrophy, mostly in glomeruli from the inner cortex. However, hypertension was not associated with podocyte loss. Absolute and relative podocyte depletion were exacerbated by the combination of older age and hypertension. The proportion of glomeruli with parietal podocytes increased with age but not with hypertension alone. These findings demonstrate that older age and hypertension are independent and additive contributors to podocyte depletion in white American men without kidney disease.
Keyword Podocyte depletion
Older age
Hypertension
Parietal epithelial cells
Glomerular Hypertrophy
Kidney disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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