A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in schizophrenia: how can we link molecular abnormalities to mismatch negativity deficits?

Catts, Vibeke S., Lai, Yan Ling, Weickert, Cyndi Shannon, Weickert, Thomas W. and Catts, Stanley V. (2016) A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in schizophrenia: how can we link molecular abnormalities to mismatch negativity deficits?. Biological Psychology, 116 57-67. doi:10.1016/j.biopsycho.2015.10.013


Author Catts, Vibeke S.
Lai, Yan Ling
Weickert, Cyndi Shannon
Weickert, Thomas W.
Catts, Stanley V.
Title A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in schizophrenia: how can we link molecular abnormalities to mismatch negativity deficits?
Formatted title
A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in schizophrenia: how can we link molecular abnormalities to mismatch negativity deficits?
Journal name Biological Psychology   Check publisher's open access policy
ISSN 1873-6246
0301-0511
Publication date 2016-04-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.biopsycho.2015.10.013
Open Access Status DOI
Volume 116
Start page 57
End page 67
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract Evidence suggests that anomalous mismatch negativity (MMN) in schizophrenia is related to glutamatergic abnormalities, possibly involving N-methyl-d-aspartate (NMDA) receptors. Decreased cortical expressions of NMDA receptor subunits have been observed in schizophrenia, though not consistently. To aid with integration and interpretation of previous work, we performed a meta-analysis of effect sizes of mRNA or protein levels of the obligatory NR1 subunit in prefrontal cortex from people with schizophrenia. In schizophrenia compared to unaffected controls the pooled effect size was −0.64 (95% confidence interval: −1.08 to −0.20) for NR1 mRNA reduction and −0.44 (95% confidence interval: −0.80 to −0.07) for NR1 protein reduction. These results represent the first step to a deeper understanding of the region-specific, cell-specific, and stage-specific NMDA receptor hypofunction in schizophrenia, which could be linked to mismatch negativity deficits via transgenic and pharmacological animal models.
Keyword Glutamate
NMDA receptor
Prefrontal cortex
Schizophrenia
Meta-analysis
Mismatch negativity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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