Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis

Ramanathan, Sudarshini, Prelog, Kristina, Barnes, Elizabeth H., Tantsis, Esther M., Reddel, Stephen W., Henderson, Andrew P. D., Vucic, Steve, Gorman, Mark P., Benson, Leslie A., Alper, Gulay, Riney, Catherine J., Barnett, Michael, Parratt, John D. E., Hardy, Todd A., Leventer, Richard J., Merheb, Vera, Nosadini, Margherita, Fung, Victor S. C., Brilot, Fabienne and Dale, Russell C. (2016) Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis. Multiple Sclerosis, 22 4: 470-482. doi:10.1177/1352458515593406


Author Ramanathan, Sudarshini
Prelog, Kristina
Barnes, Elizabeth H.
Tantsis, Esther M.
Reddel, Stephen W.
Henderson, Andrew P. D.
Vucic, Steve
Gorman, Mark P.
Benson, Leslie A.
Alper, Gulay
Riney, Catherine J.
Barnett, Michael
Parratt, John D. E.
Hardy, Todd A.
Leventer, Richard J.
Merheb, Vera
Nosadini, Margherita
Fung, Victor S. C.
Brilot, Fabienne
Dale, Russell C.
Title Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis
Journal name Multiple Sclerosis   Check publisher's open access policy
ISSN 1477-0970
1352-4585
Publication date 2016-04-01
Year available 2015
Sub-type Article (original research)
DOI 10.1177/1352458515593406
Open Access Status Not yet assessed
Volume 22
Issue 4
Start page 470
End page 482
Total pages 13
Place of publication London, United Kingdom
Publisher Sage Publications
Collection year 2017
Language eng
Formatted abstract
Background: Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes.

Objective: We aimed to define radiological features of first-episode demyelinating ON.

Methods: We performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON (MS-ON; n=13), and unclassified ON (n=7).

Results: Bilateral involvement was more common in MOG-ON and AQP4-ON than MS-ON (84% vs. 82% vs. 23%), optic nerve head swelling was more common in MOG-ON (53% vs. 9% vs. 0%), chiasmal involvement was more common in AQP4-ON (5% vs. 64% vs. 15%), and bilateral optic tract involvement was more common in AQP4-ON (0% vs. 45% vs. 0%). Retrobulbar involvement was more common in MOG-ON, whereas intracranial involvement was more common in AQP4-ON. MOG-ON and AQP4-ON had longer lesion lengths than MS-ON. The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS. AQP4-ON more frequently had severe and sustained visual impairment.

Conclusion: MOG-ON and AQP4-ON are more commonly bilateral and longitudinally extensive. MOG-ON tends to involve the anterior optic pathway, whereas AQP4-ON the posterior optic pathway.
Keyword Aquaporin-4 antibodies
Multiple sclerosis
Myelin oligodendrocyte glycoprotein antibodies
Neuromyelitis optica
Optic neuritis
Radiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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