Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus

Sobrevia, Luis, Salsoso, Rocio, Fuenzalida, Barbara, Barros, Eric, Toledo, Lilian, Silva, Luis, Pizarro, Carolina, Subiabre, Mario, Villalobos, Roberto, Araos, Joaquin, Toledo, Fernando, Gonzalez, Marcelo, Gutierrez, Jaime, Farias, Marcelo, Chiarello, Delia I., Pardo, Fabian and Leiva, Andrea (2016) Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus. Frontiers in Physiology, 7 MAR: . doi:10.3389/fphys.2016.00119


Author Sobrevia, Luis
Salsoso, Rocio
Fuenzalida, Barbara
Barros, Eric
Toledo, Lilian
Silva, Luis
Pizarro, Carolina
Subiabre, Mario
Villalobos, Roberto
Araos, Joaquin
Toledo, Fernando
Gonzalez, Marcelo
Gutierrez, Jaime
Farias, Marcelo
Chiarello, Delia I.
Pardo, Fabian
Leiva, Andrea
Title Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus
Journal name Frontiers in Physiology   Check publisher's open access policy
ISSN 1664-042X
Publication date 2016-03-31
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fphys.2016.00119
Open Access Status DOI
Volume 7
Issue MAR
Total pages 15
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2017
Language eng
Abstract Gestational diabetes mellitus (GDM) is a disease of the mother that associates with altered fetoplacental vascular function. GDM-associated maternal hyperglycaemia result in fetal hyperglycaemia, a condition that leads to fetal hyperinsulinemia and altered L-arginine transport and synthesis of nitric oxide, i.e., endothelial dysfunction. These alterations in the fetoplacental endothelial function are present in women with GDM that were under diet or insulin therapy. Since these women and their newborn show normal glycaemia at term, other factors or conditions could be altered and/or not resolved by restoring normal level of circulating D-glucose. GDM associates with metabolic disturbances, such as abnormal handling of the locally released vasodilator adenosine, and biosynthesis and metabolism of cholesterol lipoproteins, or metabolic diseases resulting in endoplasmic reticulum stress and altered angiogenesis. Insulin acts as a potent modulator of all these phenomena under normal conditions as reported in primary cultures of cells obtained from the human placenta; however, GDM and the role of insulin regarding these alterations in this disease are poorly understood. This review focuses on the potential link between insulin and endoplasmic reticulum stress, hypercholesterolemia, and angiogenesis in GDM in the human fetoplacental vasculature. Based in reports in primary culture placental endothelium we propose that insulin is a factor restoring endothelial function in GDM by reversing ERS, hypercholesterolaemia and angiogenesis to a physiological state involving insulin activation of insulin receptor isoforms and adenosine receptors and metabolism in the human placenta from GDM pregnancies.
Keyword Insulin
Gestational diabetes
Endoplasmic reticulum stress
Angiogenesis
Lipids
Placenta
Endothelium
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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