Shielding of the geomagnetic field alters actin assembly and inhibits cell motility in human neuroblastoma cells

Mo, Wei-Chuan, Zhang, Zi-Jian, Wang, Dong-Liang, Liu, Ying, Bartlett, Perry F. and He, Rong-Qiao (2016) Shielding of the geomagnetic field alters actin assembly and inhibits cell motility in human neuroblastoma cells. Scientific Reports, 6 . doi:10.1038/srep22624


Author Mo, Wei-Chuan
Zhang, Zi-Jian
Wang, Dong-Liang
Liu, Ying
Bartlett, Perry F.
He, Rong-Qiao
Title Shielding of the geomagnetic field alters actin assembly and inhibits cell motility in human neuroblastoma cells
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2016-03-31
Year available 2016
Sub-type Article (original research)
DOI 10.1038/srep22624
Open Access Status DOI
Volume 6
Total pages 15
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
Accumulating evidence has shown that absence of the geomagnetic field (GMF), the so-called hypomagnetic field (HMF) environment, alters the biological functions in seemingly non-magnetosensitive cells and organisms, which indicates that the GMF could be sensed by non-iron-rich and non-photo-sensing cells. The underlying mechanisms of the HMF effects on those cells are closely related to their GMF sensation but remain poorly understood so far. Previously, we found that the HMF represses expressions of genes associated with cell migration and cytoskeleton assembly in human neuroblastoma cells (SH-SY5Y cell line). Here, we measured the HMF-induced changes on cell morphology, adhesion, motility and actin cytoskeleton in SH-SY5Y cells. The HMF inhibited cell adhesion and migration accompanied with a reduction in cellular F-actin amount. Moreover, following exposure to the HMF, the number of cell processes was reduced and cells were smaller in size and more round in shape. Furthermore, disordered kinetics of actin assembly in vitro were observed during exposure to the HMF, as evidenced by the presence of granule and meshed products. These results indicate that elimination of the GMF affects assembly of the motility-related actin cytoskeleton, and suggest that F-actin is a target of HMF exposure and probably a mediator of GMF sensation.
Keyword Geomagnetic field
GMF
Actin assembly
Cell motility
Hypomagnetic field
HMF
Human neuroblastoma cells
SH-SY5Y cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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