Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults

Mather, Karen A., Thalamuthu, Anbupalam, Oldmeadow, Christopher, Song, Fei, Armstrong, Nicola J., Poljak, Anne, Holliday, Elizabeth G., McEvoy, Mark, Kwok, John B., Assareh, Amelia A., Reppermund, Simone, Kochan, Nicole A., Lee, Teresa, Ames, David, Wright, Margaret J., Trollor, Julian N., Schofield, Peter W., Brodaty, Henry, Scott, Rodney J., Schofield, Peter R., Attia, John R. and Sachdev, Perminder S. (2016) Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults. Scientific Reports, 6 . doi:10.1038/srep23675

Author Mather, Karen A.
Thalamuthu, Anbupalam
Oldmeadow, Christopher
Song, Fei
Armstrong, Nicola J.
Poljak, Anne
Holliday, Elizabeth G.
McEvoy, Mark
Kwok, John B.
Assareh, Amelia A.
Reppermund, Simone
Kochan, Nicole A.
Lee, Teresa
Ames, David
Wright, Margaret J.
Trollor, Julian N.
Schofield, Peter W.
Brodaty, Henry
Scott, Rodney J.
Schofield, Peter R.
Attia, John R.
Sachdev, Perminder S.
Title Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2016-03-31
Year available 2016
Sub-type Article (original research)
DOI 10.1038/srep23675
Open Access Status DOI
Volume 6
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome-wide association study of ApoH levels using the largest sample to date and replicated the results in an independent cohort (total N = 1,255). In the discovery phase, a meta-analysis of two cohorts, the Sydney Memory and Ageing Study (Sydney MAS) and the Older Australian Twins Study (OATS) (n = 942) revealed genome-wide significant results in or near the APOH gene on chromosome 17 (top SNP, rs7211380, p = 1 × 10-11). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health.
Keyword Apolipoprotein H (ApoH)
Multi-functional plasma glycoprotein
Conditional and joint analysis (COJO)
Genome-wide significant results
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Queensland Brain Institute Publications
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