Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence

Baker, Bradley, Ali, Azmat and Isenring, Liz (2016) Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutrition in Clinical Practice, 31 2: 180-185. doi:10.1177/0884533615591600


Author Baker, Bradley
Ali, Azmat
Isenring, Liz
Title Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence
Journal name Nutrition in Clinical Practice   Check publisher's open access policy
ISSN 1941-2452
0884-5336
Publication date 2016-04-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1177/0884533615591600
Open Access Status Not Open Access
Volume 31
Issue 2
Start page 180
End page 185
Total pages 6
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2016
Language eng
Formatted abstract
Introduction: Manganese (Mn) toxicity is often observed in adult patients receiving long-term home parenteral nutrition (HPN), and differing recommendations on the safe level of Mn administration to these patients have been made in the literature over the past 10 years. Methods: This systematic review used the National Health and Medical Research Council (NHMRC) evidence hierarchy to assess the design and strength of individual studies (high I to low IV) and the overall grade of evidence (grade A high to grade D low). Results: Eight studies met the inclusion criteria. Levels of evidence ranged from high (NHMRC II) to mid-level (III-3). A widespread recommendation in the literature for patients receiving long-term HPN is 55 µg (1 µmol) Mn/d. Conclusion: The recommendation of 55 µg (1µmol) Mn/d is of moderate-strength evidence (NHMRC B grade). There is limited evidence to support not supplementing Mn to patients receiving long-term HPN. Further intervention studies providing high-level evidence (II and above) are required to determine the safety of not supplementing Mn to all patients receiving long-term HPN.
Keyword Home parenteral nutrition
Hypermanganesemia
Manganese
Micronutrients
Trace elements
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 22 July 2015

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
 
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