Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging

McKenna, Benjamin S., Brown, Gregory G., Archibald, Sarah, Scadeng, Miriam, Bussell, Robert, Kesby, James P., Markou, Athina, Soontornniyomkij, Virawudh, Achim, Cristian and Semenova, Svetlana (2016) Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging. Psychiatry Research: Neuroimaging, 249 27-37. doi:10.1016/j.pscychresns.2016.02.009


Author McKenna, Benjamin S.
Brown, Gregory G.
Archibald, Sarah
Scadeng, Miriam
Bussell, Robert
Kesby, James P.
Markou, Athina
Soontornniyomkij, Virawudh
Achim, Cristian
Semenova, Svetlana
Title Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging
Journal name Psychiatry Research: Neuroimaging   Check publisher's open access policy
ISSN 1872-7506
0925-4927
Publication date 2016-03-30
Sub-type Article (original research)
DOI 10.1016/j.pscychresns.2016.02.009
Open Access Status Not Open Access
Volume 249
Start page 27
End page 37
Total pages 11
Place of publication Shannon, Clare, Ireland
Publisher Elsevier Ireland
Collection year 2017
Language eng
Formatted abstract
Methamphetamine (METH) is an addictive psychostimulant inducing neurotoxicity. Human magnetic resonance imaging and diffusion tensor imaging (DTI) of METH-dependent participants find various structural abnormities. Animal studies demonstrate immunohistochemical changes in multiple cellular pathways after METH exposure. Here, we characterized the long-term effects of METH on brain microstructure in mice exposed to an escalating METH binge regimen using in vivo DTI, a methodology directly translatable across species. Results revealed four patterns of differential fractional anisotropy (FA) and mean diffusivity (MD) response when comparing METH-exposed (n=14) to saline-treated mice (n=13). Compared to the saline group, METH-exposed mice demonstrated: 1) decreased FA with no change in MD [corpus callosum (posterior forceps), internal capsule (left), thalamus (medial aspects), midbrain], 2) increased MD with no change in FA [posterior isocortical regions, caudate-putamen, hypothalamus, cerebral peduncle, internal capsule (right)], 3) increased FA with decreased MD [frontal isocortex, corpus callosum (genu)], and 4) increased FA with no change or increased MD [hippocampi, amygdala, lateral thalamus]. MD was negatively associated with calbindin-1 in hippocampi and positively with dopamine transporter in caudate-putamen. These findings highlight distributed and differential METH effects within the brain suggesting several distinct mechanisms. Such mechanisms likely change brain tissue differentially dependent upon neural location.
Keyword Diffusion tensor imaging
Fractional anisotropy
Magnetic resonance imaging
Mean diffusivity
Methamphetamine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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