Rising prevalence of human papillomavirus–related oropharyngeal cancer in Australia over the last 2 decades

Hong, Angela, Lee, C. Soon, Jones, Deanna, Veillard, Anne-Sophie, Zhang, Mei, Zhang, Xiaoying, Smee, Robert, Corry, June, Porceddu, Sandro, Milross, Corry, Elliott, Michael, Clark, Jonathan and Rose, Barbara (2016) Rising prevalence of human papillomavirus–related oropharyngeal cancer in Australia over the last 2 decades. Head and Neck, 38 5: 743-750. doi:10.1002/hed.23942


Author Hong, Angela
Lee, C. Soon
Jones, Deanna
Veillard, Anne-Sophie
Zhang, Mei
Zhang, Xiaoying
Smee, Robert
Corry, June
Porceddu, Sandro
Milross, Corry
Elliott, Michael
Clark, Jonathan
Rose, Barbara
Title Rising prevalence of human papillomavirus–related oropharyngeal cancer in Australia over the last 2 decades
Journal name Head and Neck   Check publisher's open access policy
ISSN 1043-3074
1097-0347
Publication date 2016-05
Year available 2015
Sub-type Article (original research)
DOI 10.1002/hed.23942
Open Access Status Not Open Access
Volume 38
Issue 5
Start page 743
End page 750
Total pages 8
Place of publication Hoboken, NJ United States
Publisher John Wiley & Sons
Collection year 2017
Language eng
Formatted abstract
Background
This study provides Australian data on the characteristics of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) over the last 2 decades.

Methods
The HPV status of 515 patients with oropharyngeal SCC diagnosed between 1987 and 2010 was determined by HPV E6-targeted multiplex real time polymerase chain reaction assay (PCR) and p16 immunohistochemistry.

Results
The HPV positivity rate increased from 20.2% (1987–1995) to 63.5% (2006–2010). Among HPV-positive oropharyngeal SCC over the study period, the median age increased from 55.4 years to 59.8 years (p = .004) and there was a trend of an increasing proportion of never smokers (19.2% to 34.0%). The use of radiation therapy (RT) in patients with HPV-positive oropharyngeal cancer increased from 26.9% to 68.1% (p = .007) and we also observed a trend of improved outcomes.

Conclusion
Our data show a rising prevalence of HPV-positive oropharyngeal SCC in Australia over the last 2 decades. These patients with HPV-positive oropharyngeal SCC are now presenting at an older age and about one third have never smoked.
Keyword Human papillomavirus (HPV)
Oropharyngeal cancer
Head and neck cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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Created: Wed, 20 Apr 2016, 09:37:20 EST by Lisa Hennell on behalf of School of Medicine