Intracranial management of perineural spread in the trigeminal nerve

Redmond, Michael J. and Panizza, Benedict J. (2016) Intracranial management of perineural spread in the trigeminal nerve. Journal of Neurological Surgery, Part B: Skull Base, 77 2: 150-160. doi:10.1055/s-0036-1571838


Author Redmond, Michael J.
Panizza, Benedict J.
Title Intracranial management of perineural spread in the trigeminal nerve
Journal name Journal of Neurological Surgery, Part B: Skull Base   Check publisher's open access policy
ISSN 2193-6331
2193-634X
Publication date 2016-04
Year available 2016
Sub-type Article (original research)
DOI 10.1055/s-0036-1571838
Open Access Status Not Open Access
Volume 77
Issue 2
Start page 150
End page 160
Total pages 11
Place of publication New York, NY, United States
Publisher Thieme Medical Publishers
Collection year 2017
Language eng
Abstract Since the mid-1960s surgeons have attempted to cure intracranial perineural spread (PNS) of cutaneous malignancies. Untreated patients with trigeminal PNS die from brainstem invasion and leptomeningeal disease. It was understood that resection with clear margins was potentially curative, but early surgical attempts were unsuccessful. The prevailing wisdom considered that this surgery failed to improve the results achieved with radiation therapy alone and was associated with high morbidity. However, with improved imaging, surgical equipment, and better understanding of cavernous sinus (CS) anatomy and access, contemporary surgeons can improve outcomes for this disease. The aim of this paper is to describe a technique to access the interdural compartment of the CS and treat PNS of cutaneous squamous cell carcinoma (cSCC) in the intracranial trigeminal nerve and ganglion. It is based on the experience of the Queensland Skull Base Unit, Australia in managing PNS of cutaneous squamous cell carcinoma of the head and neck (cSCCHN).
Keyword Cavernous sinus
Interdural surgery
Meckel cave
Perineural spread
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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