Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions

Brennan, Faith H., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2016) Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions. Seminars in Immunology, 28 3: 292-308. doi:10.1016/j.smim.2016.03.015


Author Brennan, Faith H.
Lee, John D.
Ruitenberg, Marc J.
Woodruff, Trent M.
Title Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions
Journal name Seminars in Immunology   Check publisher's open access policy
ISSN 1096-3618
1044-5323
Publication date 2016
Sub-type Article (original research)
DOI 10.1016/j.smim.2016.03.015
Volume 28
Issue 3
Start page 292
End page 308
Total pages 17
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
The recognition that complement proteins are abundantly present and can have pathological roles in neurological conditions offers broad scope for therapeutic intervention. Accordingly, an increasing number of experimental investigations have explored the potential of harnessing the unique activation pathways, proteases, receptors, complexes, and natural inhibitors of complement, to mitigate pathology in acute neurotrauma and chronic neurodegenerative diseases. Here, we review mechanisms of complement activation in the central nervous system (CNS), and explore the effects of complement inhibition in cerebral ischemic-reperfusion injury, traumatic brain injury, spinal cord injury, Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease and Huntington’s disease. We consider the challenges and opportunities arising from these studies. As complement therapies approach clinical translation, we provide perspectives on how promising complement-targeted therapeutics could become part of novel and effective future treatment options to improve outcomes in the initiation and progression stages of these debilitating CNS disorders.
Keyword C5a
Complement
Neurodegeneration
Neurotrauma
Stroke
Therapeutics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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