Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations

Swift, Damon L., Johannsen, Neil M., Lavie, Carl J., Earnest, Conrad P., Blair, Steven N. and Church, Timothy S. (2016) Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations. Obesity, 24 4: 812-819. doi:10.1002/oby.21404


Author Swift, Damon L.
Johannsen, Neil M.
Lavie, Carl J.
Earnest, Conrad P.
Blair, Steven N.
Church, Timothy S.
Title Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations
Journal name Obesity   Check publisher's open access policy
ISSN 1930-739X
1930-7381
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.1002/oby.21404
Open Access Status Not Open Access
Volume 24
Issue 4
Start page 812
End page 819
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Objective: To determine response rates for clinically significant weight loss (CWL) following different aerobic exercise training amounts and whether enhanced cardiometabolic adaptations are observed with CWL compared to modest weight loss (MWL) or neither.

Methods: Participants (N = 330) performed 6 months of aerobic training at 4 kcal per kilogram per week (KKW), 8 KKW, or 12 KKW (50%, 100%, and 150% of recommended levels respectively). Weight loss was categorized as CWL (≥5%) or MWL (3.0% to 4.9%) or neither.

Results: The CWL response rate was greater in the 8 KKW group (20.2%, CI: 13.0% to 27.5%) compared to 4 KKW (10.3%, CI: 4.6% to 16.0%), but not compared to the 12 KKW group (14.6%, CI: 7.6% to 21.6%). Reductions in HOMA-IR were observed in participants with CWL (-0.60, CI: -0.98 to -0.22) and with MWL (-0.48, CI: -0.87 to -0.10), but not those who achieved neither (-0.06, CI -0.22 to 0.10). No changes between groups were observed for cholesterol, fitness, or blood pressure.

Conclusions: Low response rates for CWL were observed following training, even at levels above recommended levels. Achieving MWL with exercise may represent a reasonable initial weight loss target since the improvement in insulin resistance with MWL is similar to what is achieved with CWL.
Keyword Clinically significant weight loss (CWL)
Modest weight loss (MWL)
Cardiometabolic risk factors
Lipid profile
Insulin sensitivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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