Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome

Yan, J., Greer, J. M. and McCombe, P. A. (2016) Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome. Journal of Neuroimmunology, 293 22-27. doi:10.1016/j.jneuroim.2016.02.001

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Author Yan, J.
Greer, J. M.
McCombe, P. A.
Title Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 1872-8421
0165-5728
Publication date 2016-04-15
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jneuroim.2016.02.001
Open Access Status File (Author Post-print)
Volume 293
Start page 22
End page 27
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2017
Language eng
Abstract Our study investigated the frequency of interleukin-6 (IL-6) promoter polymorphism rs1800795 (−174 G > C), possible association of this polymorphism with IL-6 levels and the outcome after stroke in 95 patients with acute ischemic stroke and 268 healthy subjects. It shows a significant reduction in the frequency of G alleles in stroke patients compared to healthy controls. Carriage of G allele is not associated with stroke subtypes, the initial severity or the outcome after stroke. The −174 polymorphisms were not associated with variation in IL-6 levels post-stroke. Our results indicate that IL-6 promoter −174 polymorphisms may play a role in susceptibility to stroke, but not stroke outcome.
Keyword Acute ischemic stroke
Interleukin 6
Polymorphism
Immunogenetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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