The effect of exercise on vascular function and stiffness in type 2 diabetes: A systematic review and meta-analysis

Way, Kimberley Larisa, Keating, Shelley Elizabeth, Baker, Michael Kevin, Chuter, Vivienne Helaine and Johnson, Nathan Anthony (2016) The effect of exercise on vascular function and stiffness in type 2 diabetes: A systematic review and meta-analysis. Current Diabetes Reviews, 12 4: 369-383. doi:10.2174/1573399811666150817124601


Author Way, Kimberley Larisa
Keating, Shelley Elizabeth
Baker, Michael Kevin
Chuter, Vivienne Helaine
Johnson, Nathan Anthony
Title The effect of exercise on vascular function and stiffness in type 2 diabetes: A systematic review and meta-analysis
Journal name Current Diabetes Reviews   Check publisher's open access policy
ISSN 1573-3998
1875-6417
Publication date 2016-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.2174/1573399811666150817124601
Open Access Status Not yet assessed
Volume 12
Issue 4
Start page 369
End page 383
Total pages 15
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2017
Language eng
Formatted abstract
Deterioration of the structure and function of the vascular system is the underlying feature in cardiovascular disease (CVD), which is the highest cause of mortality in type 2 diabetes (T2D). Studies assessing the effect of exercise on vascular function and stiffness have used different measurement techniques and small cohorts, making it difficult to conclude on the overall efficacy of exercise on these outcomes. The aim of this study was to assess the effect of exercise on vascular function and stiffness in T2D. Electronic database searches were performed in AMED, MEDLINE, MEDLINE Daily Update, PREMEDLINE, SPORTDiscus, CINAHL, EMBASE and Web of Science. The effect size (ES), and 95% confidence intervals (CIs) of eligible studies were calculated. Pooled estimates of the effect of aerobic exercise (AEx) on vascular function and stiffness, using ES, were obtained. Results show that AEx led to a near-significant reduction in PWV (ES = -0.402, 95% CI: -0.716 to -0.088; P = 0.052), a significant reduction in EID (ES =0.416, 95% CI: 0.062 to 0.769; P= 0.021), and a non-significant benefit in FMD measures. There were limited studies using resistance training or in combination with aerobic exercise, to assess a pooled effect on vascular function or stiffness. These data suggest that aerobic exercise training should be used as a primary treatment strategy for improving vascular smooth muscle function as measured by EID in individuals with T2D. There is currently insufficient evidence concerning the efficacy of regular exercise for improving vascular function and stiffness as measured by FMD and PWV.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes http://benthamscience.com/journals/current-diabetes-reviews/article/134035/

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
 
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Created: Tue, 19 Apr 2016, 01:04:25 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences