Can transcranial direct current stimulation counteract age-associated functional impairment?

Perceval, Garon, Flöel, Agnes and Meinzer, Marcus (2016) Can transcranial direct current stimulation counteract age-associated functional impairment?. Neuroscience and Biobehavioral Reviews, 65 157-172. doi:10.1016/j.neubiorev.2016.03.028


Author Perceval, Garon
Flöel, Agnes
Meinzer, Marcus
Title Can transcranial direct current stimulation counteract age-associated functional impairment?
Journal name Neuroscience and Biobehavioral Reviews   Check publisher's open access policy
ISSN 0149-7634
1873-7528
Publication date 2016-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neubiorev.2016.03.028
Open Access Status Not Open Access
Volume 65
Start page 157
End page 172
Total pages 16
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2017
Language eng
Formatted abstract
Transcranial direct current stimulation (tDCS) can improve motor and cognitive function in young individuals and may be a viable tool to counteract age-associated functional impairment. We review the growing body of research that investigated tDCS-effects in aging and attempt to provide a framework to guide future research in this emerging field. The majority of thirty reviewed studies (N = 856 older participants) reported beneficial behavioral tDCS-effects across functional domains. Eleven studies included young and older adults and demonstrated that tDCS can restore impaired motor and cognitive functions. Several studies highlighted differences in the extent and timing of tDCS-effects between age-groups and the importance of mediating factors like baseline performance levels. Multi-session tDCS improved cognitive training outcome in two studies, however, limited transfer to untrained materials was reported. Montages inducing beneficial effects in young adults did not improve or even impaired performance in older adults in several studies. Thus, a cautious and more systematic approach that incorporates information about age-associated brain reorganization is advised when aiming to induce more permanent neuroplastic effects in older individuals in future studies.
Keyword Transcranial direct current stimulation (TDCS)
Aging
Cognition
Motor function
Learning
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
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Created: Tue, 12 Apr 2016, 11:18:06 EST by Marcus Meinzer on behalf of School of Health & Rehabilitation Sciences