Longitudinal trend in lipid profile of incident peritoneal dialysis patients is not influenced by the use of biocompatible solutions

Cho, Yeoungjee, Buchel, Janine, Steppan, Sonja, Passlick-Deetjen, Jutta, Hawley, Carmel M., Dimeski, Goce, Clarke, Margaret and Johnson, David W. (2016) Longitudinal trend in lipid profile of incident peritoneal dialysis patients is not influenced by the use of biocompatible solutions. Peritoneal Dialysis International, 36 2: 146-153. doi:10.3747/pdi.2014.00291


Author Cho, Yeoungjee
Buchel, Janine
Steppan, Sonja
Passlick-Deetjen, Jutta
Hawley, Carmel M.
Dimeski, Goce
Clarke, Margaret
Johnson, David W.
Title Longitudinal trend in lipid profile of incident peritoneal dialysis patients is not influenced by the use of biocompatible solutions
Journal name Peritoneal Dialysis International   Check publisher's open access policy
ISSN 1718-4304
0896-8608
Publication date 2016-03-01
Year available 2015
Sub-type Article (original research)
DOI 10.3747/pdi.2014.00291
Open Access Status Not Open Access
Volume 36
Issue 2
Start page 146
End page 153
Total pages 8
Place of publication Milton, ON, Canada
Publisher Multimed
Collection year 2016
Language eng
Formatted abstract
Background: The longitudinal trends of lipid parameters and the impact of biocompatible peritoneal dialysis (PD) solutions on these levels remain to be fully defined. The present study aimed to a) evaluate the influence of neutral pH, low glucose degradation product (GDP) PD solutions on serum lipid parameters, and b) explore the capacity of lipid parameters (total cholesterol [TC], triglyceride [TG], high density lipoprotein [HDL], TC/HDL, low density lipoprotein [LDL], very low density lipoprotein [VLDL]) to predict cardiovascular events (CVE) and mortality in PD patients.

Methods: The study included 175 incident participants from the balANZ trial with at least 1 stored serum sample. A composite CVE score was used as a primary clinical outcome measure. Multilevel linear regression and Poisson regression models were fitted to describe the trend of lipid parameters over time and its ability to predict composite CVE, respectively.

Results: Small but statistically significant increases in serum TG (coefficient 0.006, p < 0.001), TC/HDL (coefficient 0.004, p = 0.001), and VLDL cholesterol (coefficient 0.005, p = 0.001) levels and a decrease in the serum HDL cholesterol levels (coefficient -0.004, p = 0.009) were observed with longer time on PD, whilst the type of PD solution (biocompatible vs standard) received had no significant effect on these levels. Peritoneal dialysis glucose exposure was significantly associated with trends in TG, TC/HDL, HDL and VLDL levels. Baseline lipid parameter levels were not predictive of composite CVEs or all-cause mortality.

Conclusion: Serum TG, TC/HDL, and VLDL levels increased and the serum HDL levels decreased with increasing PD duration. None of the lipid parameters were significantly modified by biocompatible PD solution use over the time period studied or predictive of composite CVE or mortality.
Keyword Biocompatible
Cardiovascular events
Glucose degradation products
Lipid
Mortality
Peritoneal dialysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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