Infection in cystic fibrosis: impact of the environment and climate

Ramsay, K. A., Stockwell, R. E., Bell, S. C. and Kidd, T. J. (2016) Infection in cystic fibrosis: impact of the environment and climate. Expert Review of Respiratory Medicine, 10 5: 505-519. doi:10.1586/17476348.2016.1162715

Author Ramsay, K. A.
Stockwell, R. E.
Bell, S. C.
Kidd, T. J.
Title Infection in cystic fibrosis: impact of the environment and climate
Journal name Expert Review of Respiratory Medicine   Check publisher's open access policy
ISSN 1747-6356
Publication date 2016-03-28
Year available 2016
Sub-type Article (original research)
DOI 10.1586/17476348.2016.1162715
Open Access Status Not Open Access
Volume 10
Issue 5
Start page 505
End page 519
Total pages 15
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2017
Language eng
Formatted abstract
In many countries numbers of adults with cystic fibrosis (CF) exceed that of children, with median survival predicted to surpass 50 years. Increasing longevity is, in part, due to intensive therapies including eradication of early infection and suppressive therapies and pulmonary exacerbations. Initial infections with common CF pathogens are thought to arise from the natural environment. We review the impact of climate and environment on infection in CF. Specifically, several studies indicate that higher ambient temperatures, proximity to the equator and the summer season may be linked to the increased prevalence of Pseudomonas aeruginosa in people with CF. The environment may also play an important role in the acquisition of Gram negative organisms other than P. aeruginosa. There is emerging data suggesting that climatic and environmental factors are likely to impact on the risk of infection with NTM and fungi in people which are found extensively throughout the natural environment.
Keyword Acquisition
Cystic fibrosis
Environmental microbiology
Nontuberculous mycobacteria
Pseudomonas aeruginosa
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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