Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases

Brown, Ian S., Bettington, Mark L., Bettington, Andrew, Miller, Gregory and Rosty, Christophe (2016) Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases. Journal of Clinical Pathology, 69 4: 292-299. doi:10.1136/jclinpath-2015-203203

Author Brown, Ian S.
Bettington, Mark L.
Bettington, Andrew
Miller, Gregory
Rosty, Christophe
Title Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases
Journal name Journal of Clinical Pathology   Check publisher's open access policy
ISSN 1472-4146
Publication date 2016-04-01
Year available 2015
Sub-type Article (original research)
DOI 10.1136/jclinpath-2015-203203
Open Access Status Not Open Access
Volume 69
Issue 4
Start page 292
End page 299
Total pages 8
Place of publication London, United Kingdom
Publisher BMJ Group
Collection year 2016
Language eng
Formatted abstract
Aims Screening colonoscopy has led to more colorectal carcinomas presenting at an early stage potentially curable by endoscopic resection. In this study, we examined the clinical and histological features of a contemporary series of malignant colorectal polyps (MCPs) with subsequent surgical resection.

Methods We conducted a retrospective study on a consecutive series of MCPs from 239 patients, predominantly males (57.7%) with a median age of 66 years, and assessed histological parameters associated with residual disease on the surgical specimens.

Results Median MCP size was 18.6 mm, with 23.1% polyps measuring ≤10 mm. From the 140 surgical resection specimens, residual disease was identified in 20 cases, including 12 cases with metastatic lymph nodes and/or 9 cases with residual carcinoma in the large bowel wall. Histological parameters associated with nodal metastases were greater width and greater depth of the invasive component (p=0.001 and 0.006, respectively), poor differentiation (p=0.003) and a cribriform pattern (p=0.01). The risk of nodal metastases was 23.3% if two or three of these features were identified, while it was 0% and 4.5% if none or one was present, respectively. A positive margin was not associated with nodal metastasis and might be adequately treated by local endoscopic resection.

Conclusions Surgical resection should be recommended if ≥2 of these adverse histological features are present and may be warranted if one feature is present. A positive margin may require additional local resection but not necessarily surgery if no other adverse factors are present.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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